N P Jones1. 1. The Royal Eye Hospital , Manchester , United Kingdom.
Abstract
PURPOSE: To demonstrate the manifestations and complications of uveitis, and their medical and surgical management, in a very large group of patients attending the Manchester Uveitis Clinic (MUC), a specialist uveitis clinic in the Northwest of England, UK. METHODS: Retrospective retrieval of data on a computerized database incorporating all new referrals to MUC from 1991 to 2013. RESULTS: A total of 3000 new patients with uveitis were seen during a 22-year period, of which 25.2% had a single acute episode, 13.6% had acute recurrent uveitis, 20.2% had chronic fluctuating uveitis, and 41.0% had chronic unremitting uveitis. The commonest complications were cataract (35% of patients), macular edema (20.5%), and glaucoma (19.5%). Oral steroids were required in 36% of patients, oral immunosuppression in 16%, and biologic treatment in 2%. Major intraocular surgery was required in 28%. CONCLUSIONS: Oral steroid usage is not an independent risk factor for cataract formation in patients with uveitis. Oral immunosuppression usage has increased 4-fold during this study period.
PURPOSE: To demonstrate the manifestations and complications of uveitis, and their medical and surgical management, in a very large group of patients attending the Manchester Uveitis Clinic (MUC), a specialist uveitis clinic in the Northwest of England, UK. METHODS: Retrospective retrieval of data on a computerized database incorporating all new referrals to MUC from 1991 to 2013. RESULTS: A total of 3000 new patients with uveitis were seen during a 22-year period, of which 25.2% had a single acute episode, 13.6% had acute recurrent uveitis, 20.2% had chronic fluctuating uveitis, and 41.0% had chronic unremitting uveitis. The commonest complications were cataract (35% of patients), macular edema (20.5%), and glaucoma (19.5%). Oral steroids were required in 36% of patients, oral immunosuppression in 16%, and biologic treatment in 2%. Major intraocular surgery was required in 28%. CONCLUSIONS: Oral steroid usage is not an independent risk factor for cataract formation in patients with uveitis. Oral immunosuppression usage has increased 4-fold during this study period.
Authors: Ana M Roldan; Nazlee Zebardast; Maxwell Pistilli; Naira Khachatryan; Abhishek Payal; Hosne Begum; Pichaporn Artornsombudh; Siddharth S Pujari; James T Rosenbaum; H Nida Sen; Eric B Suhler; Jennifer E Thorne; Nirali P Bhatt; C Stephen Foster; Douglas A Jabs; Grace A Levy-Clarke; Robert B Nussenblatt; Jeanine M Buchanich; John H Kempen Journal: Am J Ophthalmol Date: 2021-11-13 Impact factor: 5.258
Authors: Mohammad O Tallouzi; David J Moore; Nicholas Bucknall; Philip I Murray; Melanie J Calvert; Alastair K Denniston; Jonathan M Mathers Journal: BMJ Open Ophthalmol Date: 2020-07-21
Authors: Mohammad O Tallouzi; Jonathan M Mathers; David J Moore; Philip I Murray; Nicholas Bucknall; Jane M Blazeby; Melanie Calvert; Alastair K Denniston Journal: Trials Date: 2017-12-01 Impact factor: 2.279