| Literature DB >> 25393214 |
Salvatore Di Maro1, Pasquale Zizza, Erica Salvati, Viviana De Luca, Clemente Capasso, Iolanda Fotticchia, Bruno Pagano, Luciana Marinelli, Eric Gilson, Ettore Novellino, Sandro Cosconati, Annamaria Biroccio.
Abstract
The shelterin protein TRF2 has come to the limelight for its role in telomere maintenance and tumorigenesis. Herein, the application of rational design and synthesis allowed identifying the first TRF2TRFH binder able to elicit a marked DNA damage response in cancer cells. This work paves the way for the unprecedented employment of a chemical tool to finely tune specific mechanisms underlying telomere maintenance.Entities:
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Year: 2014 PMID： 25393214 DOI： 10.1021/ja5080773
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419