Dongjie Wang1, Yanfen Lv2, Huifang Zhu3, Guifeng Lv4, Jiyi Huang5. 1. Medical Education Center, Langfang Health Vocational College, 065001. Langfang, Heibei Province, China. 2. Children Health Department, Langfang Women and Children's Health Center, 065000, Langfang, Heibei Province, China. 3. Obstetrics and Gynecology Education Center, Langfang Health Vocational College, 065001, Langfang, Heibei Province, China. 4. Traditional Chinese Medicine Education Center, Langfang Health Vocational College, 065001, Langfang, Heibei Province, China. 5. Nephrology Department, The First Affiliated Hospital of Xiamen University, Tongmin Branch Court, 361000, Xiamen, Fujian Province, China.
Abstract
BACKGROUND: The Kidney has been the target organ for the delivery of silencing ribonucleic acids (silencing RNA) administered systemically in comparison to other body tissues. MATERIALS AND METHOD: In this review, we discussed different approaches made to delivering proteins to the kidneys in different conditions like normal and pathological defects. Data from clinical experiments have been used to discuss and support the administration of silencing RNA for the treatment of kidney diseases. RESULTS: Results were achieved using the available genome wide RNA libraries. CONCLUSION: The research results are helpful in application to 3D and conventional models to find the involvement of signal pathways in kidney diseases.
BACKGROUND: The Kidney has been the target organ for the delivery of silencing ribonucleic acids (silencing RNA) administered systemically in comparison to other body tissues. MATERIALS AND METHOD: In this review, we discussed different approaches made to delivering proteins to the kidneys in different conditions like normal and pathological defects. Data from clinical experiments have been used to discuss and support the administration of silencing RNA for the treatment of kidney diseases. RESULTS: Results were achieved using the available genome wide RNA libraries. CONCLUSION: The research results are helpful in application to 3D and conventional models to find the involvement of signal pathways in kidney diseases.
Entities:
Keywords:
kidney disease; signal pathways; silencing RNA; targeting proteins