AIMS: To demonstrate the use of gadolinium (Gd)-labeled dendrimers as lymphatic imaging agents and establish the long-term biodistribution (90-day) of this type of agent in mice. MATERIALS & METHODS: A G5-Gd-BnDOTA dendrimer was prepared and injected into mice and monkeys for MR lymphangiography, and long-term biodistribution of the conjugate was studied. RESULTS: Administration of G5-Gd-BnDOTA in mice demonstrated a rapid uptake in the deep lymphatic system while injection in monkeys showed enhanced internal iliac nodes, indicating its general utility for lymphatic tracking. Biodistribution studies to 90 days showed that gadolinium conjugate is slowly being eliminated from the liver and other organs. CONCLUSION: The use of G5-Gd-BnDOTA holds great promise for lymphatic imaging, but its slow clearance from the body might hamper its eventual clinical translation.
AIMS: To demonstrate the use of gadolinium (Gd)-labeled dendrimers as lymphatic imaging agents and establish the long-term biodistribution (90-day) of this type of agent in mice. MATERIALS & METHODS: A G5-Gd-BnDOTAdendrimer was prepared and injected into mice and monkeys for MR lymphangiography, and long-term biodistribution of the conjugate was studied. RESULTS: Administration of G5-Gd-BnDOTA in mice demonstrated a rapid uptake in the deep lymphatic system while injection in monkeys showed enhanced internal iliac nodes, indicating its general utility for lymphatic tracking. Biodistribution studies to 90 days showed that gadoliniumconjugate is slowly being eliminated from the liver and other organs. CONCLUSION: The use of G5-Gd-BnDOTA holds great promise for lymphatic imaging, but its slow clearance from the body might hamper its eventual clinical translation.
Authors: Sander Langereis; Quido G de Lussanet; Marcel H P van Genderen; E W Meijer; Regina G H Beets-Tan; Arjan W Griffioen; Jos M A van Engelshoven; Walter H Backes Journal: NMR Biomed Date: 2006-02 Impact factor: 4.044
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Authors: Wojciech G Lesniak; Muhammed S T Kariapper; Bindu M Nair; Wei Tan; Alan Hutson; Lajos P Balogh; Mohamed K Khan Journal: Bioconjug Chem Date: 2007-06-13 Impact factor: 4.774
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Authors: Adrienne E Campbell-Washburn; Rajiv Ramasawmy; Matthew C Restivo; Ipshita Bhattacharya; Burcu Basar; Daniel A Herzka; Michael S Hansen; Toby Rogers; W Patricia Bandettini; Delaney R McGuirt; Christine Mancini; David Grodzki; Rainer Schneider; Waqas Majeed; Himanshu Bhat; Hui Xue; Joel Moss; Ashkan A Malayeri; Elizabeth C Jones; Alan P Koretsky; Peter Kellman; Marcus Y Chen; Robert J Lederman; Robert S Balaban Journal: Radiology Date: 2019-10-01 Impact factor: 11.105
Authors: Ana Christina L Opina; Madeleine Strickland; Yong-Sok Lee; Nico Tjandra; R Andrew Byrd; Rolf E Swenson; Olga Vasalatiy Journal: Dalton Trans Date: 2016-02-09 Impact factor: 4.390