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Literature DB >> 25392213

Abrogation of the interferon response promotes more efficient human cytomegalovirus replication.

Brian P McSharry¹, Simone K Forbes², Selmir Avdic¹, Richard E Randall³, Gavin W G Wilkinson⁴, Allison Abendroth¹, Barry Slobedman⁵.

Abstract

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling HCMV replication and provide useful tools to investigate the IFN response to HCMV.

Entities: Chemical

Mesh：

Substances：
Interferon Type I

Year: 2014 PMID： 25392213 PMCID： PMC4300662 DOI： 10.1128/JVI.02988-14

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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