M M Cherrier1, K Anderson2, J Shofer3, S Millard3, A M Matsumoto4. 1. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA cherrier@uw.edu. 2. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. 3. Geriatric, Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA. 4. Geriatric, Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Abstract
INTRODUCTION: This study investigated the effects of testosterone (T) treatment on cognition, mood, and quality of life in men with mild cognitive impairment (MCI) and low serum T levels. METHODS: A total of 351 community-dwelling men were screened, and 37 men evidenced both MCI and low T of whom 27 agreed for further screening. Twenty-two met all the study inclusion/exclusion criteria and enrolled in a 6-month randomized, double-blind, placebo-controlled study. RESULTS:Total T levels significantly increased in the T treatment group. No significant changes were observed in measures of cognition, mood, or quality of life other than improvement in 1 objective measure of verbal memory (P < .05) and decreased depression symptoms (P < .02) in the treatment group. CONCLUSIONS:Testosterone treatment may modestly improve verbal memory and depression symptoms in men with both MCI and low T.
RCT Entities:
INTRODUCTION: This study investigated the effects of testosterone (T) treatment on cognition, mood, and quality of life in men with mild cognitive impairment (MCI) and low serum T levels. METHODS: A total of 351 community-dwelling men were screened, and 37 men evidenced both MCI and low T of whom 27 agreed for further screening. Twenty-two met all the study inclusion/exclusion criteria and enrolled in a 6-month randomized, double-blind, placebo-controlled study. RESULTS: Total T levels significantly increased in the T treatment group. No significant changes were observed in measures of cognition, mood, or quality of life other than improvement in 1 objective measure of verbal memory (P < .05) and decreased depression symptoms (P < .02) in the treatment group. CONCLUSIONS:Testosterone treatment may modestly improve verbal memory and depression symptoms in men with both MCI and low T.
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