Literature DB >> 25391616

Health professionals' evaluation of delivering treatment-focused genetic testing to women newly diagnosed with breast cancer.

Kirsten F L Douma1, Bettina Meiser, Judy Kirk, Gillian Mitchell, Christobel Saunders, Belinda Rahman, Mariana S Sousa, Kristine Barlow-Stewart, Margaret Gleeson, Kathy Tucker.   

Abstract

Increasingly, women are offered genetic testing shortly after diagnosis of breast cancer to facilitate decision-making about treatment, often referred to as 'treatment-focused genetic testing' (TFGT). As understanding the attitudes of health professionals is likely to inform its integration into clinical care we surveyed professionals who participated in our TFGT randomized control study. Thirty-six completed surveys were received (response rate 59%), 15 (42%) health professionals classified as genetic and 21 (58%) as non-genetic. Mainly positive experiences with participating in the TFGT trial were reported. The high cost of testing and who could best deliver information about TGFT to the patient were raised as key constraints to implementation of TFGT in usual care. More non-genetic than genetic health professionals (44 vs 8%) preferred that the surgeon provide the information for decision-making about TFGT. While costs of TFGT itself and the time and effort of staff involved were perceived barriers, as testing costs become lower, it is expected that TFGT will become a routine part of standard clinical care for patients at high genetic risk in the near future.

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Year:  2015        PMID: 25391616     DOI: 10.1007/s10689-014-9770-z

Source DB:  PubMed          Journal:  Fam Cancer        ISSN: 1389-9600            Impact factor:   2.375


  15 in total

1.  Getting to the point: what women newly diagnosed with breast cancer want to know about treatment-focused genetic testing.

Authors:  Bettina Meiser; Margaret Gleeson; Kaaren Watts; Michelle Peate; Elvira Zilliacus; Kristine Barlow-Stewart; Christobel Saunders; Gillian Mitchell; Judy Kirk
Journal:  Oncol Nurs Forum       Date:  2012-03       Impact factor: 2.172

2.  There is no decision to make: experiences and attitudes toward treatment-focused genetic testing among women diagnosed with ovarian cancer.

Authors:  B Meiser; M Gleeson; N Kasparian; K Barlow-Stewart; M Ryan; K Watts; D Menon; G Mitchell; K Tucker
Journal:  Gynecol Oncol       Date:  2011-10-26       Impact factor: 5.482

3.  Too much, too soon? Patients and health professionals' views concerning the impact of genetic testing at the time of breast cancer diagnosis in women under the age of 40.

Authors:  A Ardern-Jones; R Kenen; R Eeles
Journal:  Eur J Cancer Care (Engl)       Date:  2005-07       Impact factor: 2.520

4.  Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers.

Authors:  L C Hartmann; T A Sellers; D J Schaid; T S Frank; C L Soderberg; D L Sitta; M H Frost; C S Grant; J H Donohue; J E Woods; S K McDonnell; C W Vockley; A Deffenbaugh; F J Couch; R B Jenkins
Journal:  J Natl Cancer Inst       Date:  2001-11-07       Impact factor: 13.506

5.  Primary care physicians' knowledge and attitudes towards genetic testing for breast-ovarian cancer predisposition.

Authors:  M Escher; A P Sappino
Journal:  Ann Oncol       Date:  2000-09       Impact factor: 32.976

6.  Communication and information needs of women diagnosed with ovarian cancer regarding treatment-focused genetic testing.

Authors:  Margaret Gleeson; Bettina Meiser; Kristine Barlow-Stewart; Alison H Trainer; Kathy Tucker; Kaaren J Watts; Michael Friedlander; Nadine Kasparian
Journal:  Oncol Nurs Forum       Date:  2013-05-01       Impact factor: 2.172

7.  BRCA testing of breast cancer patients: medical specialists' referral patterns, knowledge and attitudes to genetic testing.

Authors:  E Van Riel; C C Wárlám-Rodenhuis; S Verhoef; E J T H Rutgers; M G E M Ausems
Journal:  Eur J Cancer Care (Engl)       Date:  2009-07-29       Impact factor: 2.520

8.  A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2 genes.

Authors:  Heather L Hondow; Stephen B Fox; Gillian Mitchell; Rodney J Scott; Victoria Beshay; Stephen Q Wong; Alexander Dobrovic
Journal:  BMC Cancer       Date:  2011-06-24       Impact factor: 4.430

Review 9.  Genetic counselling and testing for inherited gene mutations in newly diagnosed patients with breast cancer: a review of the existing literature and a proposed research agenda.

Authors:  Bettina Meiser; Kathy Tucker; Michael Friedlander; Kristine Barlow-Stewart; Elizabeth Lobb; Christobel Saunders; Gillian Mitchell
Journal:  Breast Cancer Res       Date:  2008-11-28       Impact factor: 6.466

10.  Impact of rapid genetic counselling and testing on the decision to undergo immediate or delayed prophylactic mastectomy in newly diagnosed breast cancer patients: findings from a randomised controlled trial.

Authors:  M R Wevers; N K Aaronson; S Verhoef; E M A Bleiker; D E E Hahn; M A Kuenen; J van der Sanden-Melis; T Brouwer; F B L Hogervorst; R B van der Luijt; H B Valdimarsdottir; T van Dalen; E B M Theunissen; B van Ooijen; M A de Roos; P J Borgstein; B C Vrouenraets; E Vriens; W H Bouma; H Rijna; J P Vente; A J Witkamp; E J T Rutgers; M G E M Ausems
Journal:  Br J Cancer       Date:  2014-01-14       Impact factor: 7.640

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  6 in total

1.  Cancer Genetic Counselors' Current Practices and Attitudes Related to the Use of Tumor Profiling.

Authors:  LeAnne Noelle Goedde; Nathan W Stupiansky; Melissa Lah; Kimberly A Quaid; Stephanie Cohen
Journal:  J Genet Couns       Date:  2017-01-13       Impact factor: 2.537

Review 2.  The composition and capacity of the clinical genetics workforce in high-income countries: a scoping review.

Authors:  Nick Dragojlovic; Kennedy Borle; Nicola Kopac; Ursula Ellis; Patricia Birch; Shelin Adam; Jan M Friedman; Amy Nisselle; Alison M Elliott; Larry D Lynd
Journal:  Genet Med       Date:  2020-06-24       Impact factor: 8.822

3.  Cancer Predisposition Cascade Screening for Hereditary Breast/Ovarian Cancer and Lynch Syndromes in Switzerland: Study Protocol.

Authors:  Maria C Katapodi; Valeria Viassolo; Maria Caiata-Zufferey; Christos Nikolaidis; Nicole Buerki; Karl Heinimann; Viola Heinzelmann-Schwarz; Olivia Pagani; Pierre O Chappuis; Rosmarie Bührer-Landolt; Rossella Graffeo; Henrik Csaba Horváth; Christian Kurzeder; Manuela Rabaglio; Michael Scharfe; Corinne Urech; Tobias E Erlanger; Nicole Probst-Hensch
Journal:  JMIR Res Protoc       Date:  2017-09-20

4.  Factors influencing cancer genetic somatic mutation test ordering by cancer physician.

Authors:  Anastassia Demeshko; David J Pennisi; Sushil Narayan; Stacy W Gray; Matthew A Brown; Aideen M McInerney-Leo
Journal:  J Transl Med       Date:  2020-11-12       Impact factor: 5.531

5.  Universal Germline Genetic Testing for Hereditary Cancer Syndromes in Patients With Solid Tumor Cancer.

Authors:  Edward D Esplin; Sarah M Nielsen; Sara L Bristow; Judy E Garber; Heather Hampel; Huma Q Rana; N Jewel Samadder; Neal D Shore; Robert L Nussbaum
Journal:  JCO Precis Oncol       Date:  2022-09

6.  Moving into the mainstream: healthcare professionals' views of implementing treatment focussed genetic testing in breast cancer care.

Authors:  Nina Hallowell; S Wright; D Stirling; C Gourley; O Young; M Porteous
Journal:  Fam Cancer       Date:  2019-07       Impact factor: 2.375

  6 in total

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