PURPOSE: To describe an ocular manifestation of Castleman disease, a rare lymphoproliferative disorder characterized by sheets of abundant plasma cells in the interfollicular spaces of lymph nodes, most commonly in the abdomen, mediastinum, and cervical chain. METHODS: Clinicopathologic case report. PATIENT: A 69-year-old man with lymphadenopathy and bilateral choroidal infiltrates. RESULTS: Initially, we suspected systemic lymphoma with ocular involvement. Lymph node biopsy revealed Castleman disease without a monoclonal component. Choroidal biopsy showed lymphocytic and plasma cell infiltration. CONCLUSION: To our knowledge, this is the first clinicopathologic report of multicentric Castleman disease involving the eye.
PURPOSE: To describe an ocular manifestation of Castleman disease, a rare lymphoproliferative disorder characterized by sheets of abundant plasma cells in the interfollicular spaces of lymph nodes, most commonly in the abdomen, mediastinum, and cervical chain. METHODS: Clinicopathologic case report. PATIENT: A 69-year-old man with lymphadenopathy and bilateral choroidal infiltrates. RESULTS: Initially, we suspected systemic lymphoma with ocular involvement. Lymph node biopsy revealed Castleman disease without a monoclonal component. Choroidal biopsy showed lymphocytic and plasma cell infiltration. CONCLUSION: To our knowledge, this is the first clinicopathologic report of multicentric Castleman disease involving the eye.
Authors: David T L Liu; Jerry A Shields; C L Li; H K Ng; Dennis S C Lam Journal: Graefes Arch Clin Exp Ophthalmol Date: 2011-06-16 Impact factor: 3.117