Nan-Kai Wang1, Chai Lin Chou, Stephen H Tsang. 1. From the *Department of Pathology, Bernard and Shirlee Brown Glaucoma Laboratory, Edward S. Harkness Eye Institute, New York, New York; †Department of Ophthalmology, Chang Gung Memorial Hospital, Linkon, Taiwan; and ‡Chang Gung University College of Medicine, Tao-Yuan, Taiwan.
Abstract
PURPOSE: The purpose of this study was to compare fluorescein angiography, infrared imaging, fundus autofluorescence, and optical coherent tomography for the diagnosing and monitoring of Harada disease. METHODS: This was an interventional case report. RESULTS: A 46-year-old Chinese woman presented with headache, tinnitus, and diminished vision in both eyes. Examination revealed bilateral exudative retinal detachment. Optical coherence tomography showed fluid accumulation in three different layers (intraretinal, subretinal, and subretinal pigment epithelium). Fundus autofluorescence revealed regions of hypoautofluorescence as a result of the thick fluid accumulation. Infrared imaging revealed more clinically relevant information than did fundus autofluorescence in this case. CONCLUSION: In Harada disease, excessive fluid accumulates in three different layers. Optical coherence tomography is the most effective modality in measuring the axial distribution of the fluid in the z-plane, whereas infrared imaging is better at providing the information in the x-y plane, compared with fundus autofluorescence.
PURPOSE: The purpose of this study was to compare fluorescein angiography, infrared imaging, fundus autofluorescence, and optical coherent tomography for the diagnosing and monitoring of Harada disease. METHODS: This was an interventional case report. RESULTS: A 46-year-old Chinese woman presented with headache, tinnitus, and diminished vision in both eyes. Examination revealed bilateral exudative retinal detachment. Optical coherence tomography showed fluid accumulation in three different layers (intraretinal, subretinal, and subretinal pigment epithelium). Fundus autofluorescence revealed regions of hypoautofluorescence as a result of the thick fluid accumulation. Infrared imaging revealed more clinically relevant information than did fundus autofluorescence in this case. CONCLUSION: In Harada disease, excessive fluid accumulates in three different layers. Optical coherence tomography is the most effective modality in measuring the axial distribution of the fluid in the z-plane, whereas infrared imaging is better at providing the information in the x-y plane, compared with fundus autofluorescence.
Authors: R J Antcliff; M R Stanford; D S Chauhan; E M Graham; D J Spalton; J S Shilling; T J Ffytche; J Marshall Journal: Ophthalmology Date: 2000-03 Impact factor: 12.079