Rebound neovascularization during bevacizumab therapy.

PURPOSE: To present two cases of rebound neovascularization after bevacizumab treatment.
METHODS: Observational, retrospective case report. A 42-year-old male patient with proliferative diabetic retinopathy and a 68-year-old man with central retinal vein occlusion received treatment with panretinal photocoagulation and intravitreal bevacizumab.
RESULTS: Both patients showed significant improvement with regression of neovascular vessels after treatment. Nevertheless, on cessation of treatment because of loss to follow-up, both presented with massive neovascularization. This was significantly more severe than the initial presentation.
CONCLUSION: After initial suppression of vascular endothelial growth factor by bevacizumab, a rebound phenomenon of neovascularization can occur.