Neil G Simon1,2,3, Jeffrey W Ralph1, Catherine Lomen-Hoerth1, Ann N Poncelet1, Steve Vucic2,4, Matthew C Kiernan5, Michel Kliot6. 1. Department of Neurology, University of California, San Francisco, San Francisco, California, USA. 2. Neuroscience Research Australia, PO Box 1165, Randwick NSW 2031, Australia. 3. Prince of Wales Clinical School, University of New South Wales, Australia. 4. Westmead Clinical School, C24 Westmead Hospital, The University of Sydney, NSW 2006, Australia. 5. Brain and Mind Research Institute, The University of Sydney, Mallett St, Camperdown, Australia. 6. Department of Neurological Surgery, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA.
Abstract
INTRODUCTION: Presentations to the neuromuscular clinic commonly involve hand muscle denervation, but few studies have evaluated hand muscle ultrasound. METHODS: Ultrasound studies of abductor pollicis brevis, first dorsal interosseous, and abductor digit minimi were prospectively performed in a cohort of 34 patients (77 muscles) with electromyography (EMG)-confirmed denervation, compared with 58 healthy control subjects. RESULTS: In control subjects, muscle thickness was highly reproducible [intraclass correlation coefficient (ICC) = 0.88-0.98], and echogenicity was moderately reproducible (ICC = 0.542-0.686). Age, gender, and body mass index influenced muscle thickness and echogenicity. Ultrasound changes in denervated muscles correlated with the severity of EMG abnormalities. A z-score cutoff of 0 identified denervated muscles with a sensitivity of 100% and 89% for echogenicity and muscle thickness, respectively. CONCLUSIONS: Hand muscle ultrasound provides a noninvasive method to quantify muscle denervation and may be useful as a screening tool before EMG studies.
INTRODUCTION: Presentations to the neuromuscular clinic commonly involve hand muscle denervation, but few studies have evaluated hand muscle ultrasound. METHODS: Ultrasound studies of abductor pollicis brevis, first dorsal interosseous, and abductor digit minimi were prospectively performed in a cohort of 34 patients (77 muscles) with electromyography (EMG)-confirmed denervation, compared with 58 healthy control subjects. RESULTS: In control subjects, muscle thickness was highly reproducible [intraclass correlation coefficient (ICC) = 0.88-0.98], and echogenicity was moderately reproducible (ICC = 0.542-0.686). Age, gender, and body mass index influenced muscle thickness and echogenicity. Ultrasound changes in denervated muscles correlated with the severity of EMG abnormalities. A z-score cutoff of 0 identified denervated muscles with a sensitivity of 100% and 89% for echogenicity and muscle thickness, respectively. CONCLUSIONS: Hand muscle ultrasound provides a noninvasive method to quantify muscle denervation and may be useful as a screening tool before EMG studies.
Authors: Chao-Ying Chen; Corey W McGee; Tonya L Rich; Cecília N Prudente; Bernadette T Gillick Journal: J Hand Ther Date: 2017-08-12 Impact factor: 1.950
Authors: Ji Soo Choi; Han Gil Seo; Byung-Mo Oh; Hongyoon Choi; Gi Jeong Cheon; Shi-Uk Lee; Seung Hak Lee Journal: Ann Clin Transl Neurol Date: 2019-10-06 Impact factor: 4.511