| Literature DB >> 25388266 |
Peter A Nigrovic1, Kichul Shin.
Abstract
Mast cells are innate immune effector cells that reside in the healthy synovial sublining and expand in number with inflammation. These cells can play an important role in initiation of arthritis, but much about their biology and importance remains obscure. This chapter reviews the use of animal models for the study of mast cells in arthritis, with a particular focus on the K/BxN serum transfer model. We discuss tissue preparation and histological analysis for the assessment of joint inflammation, injury, and the presence and phenotype of synovial mast cells, as well as the use of bone marrow-derived mast cell (BMMC) engraftment into W/Wv mice as a tool to isolate the role of mast cells in joint inflammation and injury.Entities:
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Year: 2015 PMID： 25388266 PMCID： PMC6817810 DOI： 10.1007/978-1-4939-1568-2_26
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745