K Liu1, S Yang, M Hou, T Chen, J Liu, B Yu. 1. Key Laboratory of Myocardial Ischemia Mechanism and Treatment, Chinese Ministry of Education, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086, Harbin, Heilongjiang Province, China.
Abstract
BACKGROUND: The role of circulating stromal cell-derived factor-1 (SDF-1) in heart failure (HF) has not been defined. The aim of this study was to examine the circulating SDF-1 levels in hospitalized heart failure (HHF) patients. METHODS: Circulating SDF-1 and other clinical variables, including N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and echocardiographic parameters, were measured in HHF patients (n = 69) and healthy control subjects (n = 35). RESULTS: The circulating SDF-1 level was significantly greater in patients with HF (5,101 ± 1,977 pg/ml) compared with the control subjects (1,879 ± 1,417 pg/ml; p < 0.001). Circulating SDF-1 levels were positively correlated with NT-proBNP (r = 0.46 p < 0.001) and CRP (r = 0.53 p < 0.001) levels, and negatively correlated with left ventricular ejection fraction values (r = - 0.41, p < 0.001). CONCLUSION: The level of circulating SDF-1 increases in HHF patients.
BACKGROUND: The role of circulating stromal cell-derived factor-1 (SDF-1) in heart failure (HF) has not been defined. The aim of this study was to examine the circulating SDF-1 levels in hospitalized heart failure (HHF) patients. METHODS: Circulating SDF-1 and other clinical variables, including N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and echocardiographic parameters, were measured in HHF patients (n = 69) and healthy control subjects (n = 35). RESULTS: The circulating SDF-1 level was significantly greater in patients with HF (5,101 ± 1,977 pg/ml) compared with the control subjects (1,879 ± 1,417 pg/ml; p < 0.001). Circulating SDF-1 levels were positively correlated with NT-proBNP (r = 0.46 p < 0.001) and CRP (r = 0.53 p < 0.001) levels, and negatively correlated with left ventricular ejection fraction values (r = - 0.41, p < 0.001). CONCLUSION: The level of circulating SDF-1 increases in HHF patients.
Authors: Arne Yndestad; Jan Kristian Damås; Erik Øie; Thor Ueland; Lars Gullestad; Pål Aukrust Journal: Curr Cardiol Rep Date: 2007-05 Impact factor: 2.931
Authors: Yao Liang Tang; Wuqiang Zhu; Min Cheng; Lijuan Chen; John Zhang; Tao Sun; Raj Kishore; M Ian Phillips; Douglas W Losordo; Gangjian Qin Journal: Circ Res Date: 2009-04-30 Impact factor: 17.367
Authors: Daniel J Ceradini; Anita R Kulkarni; Matthew J Callaghan; Oren M Tepper; Nicholas Bastidas; Mark E Kleinman; Jennifer M Capla; Robert D Galiano; Jamie P Levine; Geoffrey C Gurtner Journal: Nat Med Date: 2004-07-04 Impact factor: 53.440