Positron range in PET imaging: non-conventional isotopes.

In addition to conventional short-lived radionuclides, longer-lived isotopes are becoming increasingly important to positron emission tomography (PET). The longer half-life both allows for circumvention of the in-house production of radionuclides, and expands the spectrum of physiological processes amenable to PET imaging, including processes with prohibitively slow kinetics for investigation with short-lived radiotracers. However, many of these radionuclides emit 'high-energy' positrons and gamma rays which affect the spatial resolution and quantitative accuracy of PET images. The objective of the present work is to investigate the positron range distribution for some of these long-lived isotopes. Based on existing Monte Carlo simulations of positron interactions in water, the probability distribution of the line of response displacement have been empirically described by means of analytic displacement functions. Relevant distributions have been derived for the isotopes (22)Na, (52)Mn, (89)Zr, (45)Ti, (51)Mn, (94 m)Tc, (52 m)Mn, (38)K, (64)Cu, (86)Y, (124)I, and (120)I. It was found that the distribution functions previously found for a series of conventional isotopes (Jødal et al 2012 Phys. Med. Bio. 57 3931-43), were also applicable to these non-conventional isotopes, except that for (120)I, (124)I, (89)Zr, (52)Mn, and (64)Cu, parameters in the formulae were less well predicted by mean positron energy alone. Both conventional and non-conventional range distributions can be described by relatively simple analytic expressions. The results will be applicable to image-reconstruction software to improve the resolution.