| Literature DB >> 25386768 |
Ling Li1, Zheng Li, Kailiang Wang, Sheng Zhao, Jiming Feng, Jiarui Li, Peiwen Yang, Yuxiu Liu, Lizhong Wang, Yongqiang Li, Hui Shang, Qingmin Wang.
Abstract
A series of aromatic gossypol Schiff bases have been successfully synthesized via a feasible chemical modification. The antiviral activity against tobacco mosaic virus (TMV) of these gossypol Schiff bases has been tested for the first time. The bioassay studies indicated most of these derivatives exhibited excellent anti-TMV activity, in which o-trifluoromethylaniline Schiff base (19) displayed the best antiviral activities. Furthermore, compound 19 exhibited an eminent anti-TMV effect in the field and low toxicity to mice. These results suggest it is a promising candidate for the inhibitor of plant virus.Entities:
Keywords: Schiff base; anti-TMV activity; gossypol; structure−activity relationships; synthesis
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Year: 2014 PMID： 25386768 DOI： 10.1021/jf504411g
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279