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Literature DB >> 2538675

cAMP levels in monocytes of heroin addicts.

J L Castrillón¹, J L Arellano, J D Palomo, M M Rodriguez, A J López.

Abstract

Intravenous heroin addicts have a high intracellular cAMP level in relation to control monocytes. Incubation in vitro with ascorbic acid normalizes the cellular content of cAMP. We discuss the role of cAMP in the pathogenesis of defective monocyte chemotaxis in intravenous heroin addicts.

Entities: Chemical Gene

Mesh：

Substances：
Cyclic AMP
Ascorbic Acid

Year: 1989 PMID： 2538675 DOI： 10.1007/bf01717325

Source DB: PubMed Journal: Klin Wochenschr ISSN： 0023-2173

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References

13 in total

1. Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion.

Authors: J I Gallin; J A Sandler; R I Clyman; V C Manganiello; M Vaughan
Journal: J Immunol Date: 1978-02 Impact factor: 5.422

2. "In vitro" improvement of defective monocyte chemotaxis in intravenous drug abusers after incubation with ascorbic acid.

Authors: A J Lopez; D G Palomo; J L Castrillon; J L Arellano
Journal: Klin Wochenschr Date: 1987-07-01

10. Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes.

Authors: P Y Law; D S Hom; H H Loh
Journal: Mol Pharmacol Date: 1983-11 Impact factor: 4.436

cAMP levels in monocytes of heroin addicts.

1. Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion.

2. "In vitro" improvement of defective monocyte chemotaxis in intravenous drug abusers after incubation with ascorbic acid.

3. The role of hormone receptors and GTP-regulatory proteins in membrane transduction.

4. A simple method of obtaining monocytes in suspension.

5. Stereoselective muscarinic acetylcholine and opiate receptiors in human phagocytic leukocytes.

6. Cyclic nucleotides regulate the morphologic alterations required for chemotaxis in monocytes.

7. Hormonal activation of adenylate cyclase in macrophage membranes is regulated by guanine nucleotides.

8. Ascorbate suppresses the opiate-induced compensatory increase in cyclic AMP in neuroblastoma X glioma hybrid cells.

9. Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate.

10. Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes.