Juho Suojanen1, Niko Lehtonen1, Esa Färkkilä2, Jarkko Hietanen3, Olli Teronen1, Timo Sorsa4, Jaana Hagström5. 1. Faculty, Department of Cell Biology of Oral Diseases, Institute of Dentistry, University of Helsinki, Finland and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital , Finland . 2. Faculty, Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital , Finland . 3. Faculty, Department of Oral Pathology, Institute of Dentistry, University of Helsinki , Finland and HUSLAB . 4. Faculty, Department of Cell Biology of Oral Diseases, Institute of Dentistry, University of Helsinki, Finland and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland and Division of Periodontology, Department of Dental Medicine, Karolinska Institutet , Huddinge, Sweden . 5. Faculty, Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Finland and HUSLAB and Department of Pathology, at the Haartman Institute and HUSLAB, Helsinki University Central Hospital , Finland .
Abstract
OBJECTIVE: Mechanisms of the dentigerous cyst formation from the normal eruption follicle is unknown but disturbances in the proteolytic activity have been suspected, since the growth of these cysts is accompanied by local bone destruction. The aim of the present study was to evaluate the expression of matrix metalloproteinases (MMP) in human dental dentigerous cysts and healthy dental follicles. MATERIALS AND METHODS: We studied 10 patients with dentigerous cysts and 10 healthy dental follicles from the lower jaw in respect to their immunoexpression of MMPs -8, -9, -25, and -26 and tissue inhibitor of metalloproteinases -1 (TIMP-1). RESULTS: MMP-8 was expressed slightly more in cyst epithelium than in odontogenic epithelium of healthy controls dental follicle but the difference lacked statistical difference. Other MMPs and TIMP-1 did not differ regarding the studied specimens. CONCLUSION: Differences in MMP expression cannot solely explain the cyst expansion suggesting the potential involvement of other osteolytic mechanisms.
OBJECTIVE: Mechanisms of the dentigerous cyst formation from the normal eruption follicle is unknown but disturbances in the proteolytic activity have been suspected, since the growth of these cysts is accompanied by local bone destruction. The aim of the present study was to evaluate the expression of matrix metalloproteinases (MMP) in human dental dentigerous cysts and healthy dental follicles. MATERIALS AND METHODS: We studied 10 patients with dentigerous cysts and 10 healthy dental follicles from the lower jaw in respect to their immunoexpression of MMPs -8, -9, -25, and -26 and tissue inhibitor of metalloproteinases -1 (TIMP-1). RESULTS:MMP-8 was expressed slightly more in cyst epithelium than in odontogenic epithelium of healthy controls dental follicle but the difference lacked statistical difference. Other MMPs and TIMP-1 did not differ regarding the studied specimens. CONCLUSION: Differences in MMP expression cannot solely explain the cyst expansion suggesting the potential involvement of other osteolytic mechanisms.
Authors: Juho Suojanen; Suvi-Tuuli Vilen; Pia Nyberg; Pia Heikkilä; Oula Penate-Medina; Per E J Saris; Jaana Hagström; Tanja-Maria Ranta; Tuula Salo; Timo Sorsa; Justus Reunanen Journal: Anticancer Res Date: 2011-11 Impact factor: 2.480
Authors: Emma Pirilä; Jarkko T Korpi; Timo Korkiamäki; Tiina Jahkola; Ana Gutierrez-Fernandez; Carlos Lopez-Otin; Ulpu Saarialho-Kere; Tuula Salo; Timo Sorsa Journal: Wound Repair Regen Date: 2007 Jan-Feb Impact factor: 3.617
Authors: André Luis Ribeiro Ribeiro; Rafaela M Nobre; Sérgio M Alves-Junior; Maria S S Kataoka; Regina F F Barroso; Ruy G Jaeger; João J V Pinheiro Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2012-10
Authors: Jaana Wahlgren; Anu Väänänen; Olli Teronen; Timo Sorsa; Emma Pirilä; Jarkko Hietanen; Päivi Maisi; Leo Tjäderhane; Tuula Salo Journal: J Oral Pathol Med Date: 2003-02 Impact factor: 4.253