Literature DB >> 25386499

Synchronous presentation of chronic myeloid leukemia with carcinoma penis: a rare presentation.

Abhijeet P Ganapule1, Vivi Srivasvas Tavaavaava2, Ramani Manoj Kumar3, Nirmal T J4, Auro Viswabandya5.   

Abstract

We report here a case of 52-year-old male presenting with penile ulcer. On evaluation, he was diagnosed to have Carcinoma penis with concurrent CML in chronic phase. Clinical examination showed pallor, bilateral inguinal lymphadenopathy, bilateral pitting pedal oedema and hepatosplenomegaly. He was diagnosed to have chronic myeloid leukemia based on peripheral smear examination showing raised counts with shift to left and fluorescence in situ hydridisation (FISH) showing t (9:22). The ilio-inguinal block dissection specimen showed inguinal metastasis of squamous cell carcinoma (SCC). This case is being presented here in view of the rarity in combination of CML with another malignancy.

Entities:  

Keywords:  Chronic myeloid leukemia- chronic phase (CML-CP); Fluorescence in situ hybridization (FISH); Squamous cell carcinoma (SCC)

Year:  2014        PMID: 25386499      PMCID: PMC4225951          DOI: 10.7860/JCDR/2014/8760.4827

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  10 in total

Review 1.  The molecular biology of chronic myeloid leukemia.

Authors:  M W Deininger; J M Goldman; J V Melo
Journal:  Blood       Date:  2000-11-15       Impact factor: 22.113

2.  EAU penile cancer guidelines 2009.

Authors:  Giorgio Pizzocaro; Ferran Algaba; Simon Horenblas; Eduard Solsona; Silvia Tana; Hein Van Der Poel; Nicholas A Watkin
Journal:  Eur Urol       Date:  2010-02-04       Impact factor: 20.096

Review 3.  Chronic myeloid leukemia following radiotherapy for carcinoma of the cervix: report of a case and brief review of the literature.

Authors:  A Ugur Ural; Murat Beyzadeoglu; Ferit Avcu; Oral Nevruz
Journal:  Am J Hematol       Date:  2007-05       Impact factor: 10.047

4.  Second primary head and neck squamous cell cancers with aggressive behavior in patients with chronic myeloid leukaemia.

Authors:  Ashwini Budrukkar; Sidramesh Muttagi; Tanveer Shahid; Pankaj Chatturvedi; Shripad Banavali; Sarbani Ghosh Laskar; Vedang Murthy; Anil D'Cruz; Jai Prakash Agarwal
Journal:  Br J Oral Maxillofac Surg       Date:  2011-11-25       Impact factor: 1.651

5.  [Chronic granulocytic leukemia and an organ neoplasm in the same person].

Authors:  A Gola; A Reszko
Journal:  Pol Tyg Lek       Date:  1996-05

Review 6.  The Biology of CML blast crisis.

Authors:  Jerald P Radich
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2007

7.  Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck.

Authors:  J A Brennan; J O Boyle; W M Koch; S N Goodman; R H Hruban; Y J Eby; M J Couch; A A Forastiere; D Sidransky
Journal:  N Engl J Med       Date:  1995-03-16       Impact factor: 91.245

8.  Imatinib-related bone marrow aplasia after complete cytogenetic response in chronic myeloid leukemia.

Authors:  Khurshid Ahmed Khan; Ayesha Junaid; Nauman Saleem Siddiqui; Khalida Mukhtar; Saleem Siddiqui
Journal:  J Coll Physicians Surg Pak       Date:  2008-03       Impact factor: 0.711

9.  Natural killer and lymphokine-activated killer cell functions in chronic myeloid leukemia.

Authors:  N Rajaram; R J Tatake; S H Advani; S L Naik; S G Gangal
Journal:  Cancer Immunol Immunother       Date:  1990       Impact factor: 6.968

10.  Squamous cutaneous epithelial cell carcinoma in two CML patients with progressive disease under imatinib treatment.

Authors:  Gökben Baskaynak; Karl-Anton Kreuzer; Michaela Schwarz; Johannes Zuber; Heike Audring; Hanno Riess; Bernd Dörken; Philipp le Coutre
Journal:  Eur J Haematol       Date:  2003-04       Impact factor: 2.997

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.