OBJECTIVES: To compare the efficacy of topical antifungal agents, Sertaconazole and Clotrimazole in Tinea corporis patients. MATERIALS AND METHODS: A total of 60(n=60) patients were included in the study. They were divided into two groups of 30 patients each. First group included patients treated with topical Sertaconazole as test drug whereas the second group constituted patients treated with topical Clotrimazole as standard drug. The patients were advised to apply the drug on affected area twice daily for three weeks. The parameters like erythema, scaling, itching, margins and size of the lesion and KOH mount were taken for the assessment of efficacy. This was an open labelled study and patients were followed up every week for three weeks. RESULTS: The total score included all grades in erythema, itching, scaling, margins and size of lesion and KOH mount. There was significant reduction in erythema (p<0.02) and highly significant reduction in scaling (p<0.001), itching (p<0.001) and margins of lesion (p<0.001) among Sertaconazole group. The mean difference and the standard deviation of total scores for Clotrimazole were 7.20 and 1.69 and for Sertaconazole group 8.80 and 1.52 respectively. The p-value on application of students unpaired t- test was p<0.001 (Highly significant). CONCLUSION: From the present study, it can be concluded that topical Sertaconazole shows better improvement in the clinical parameters than topical Clotrimazole within a span of three weeks in the treatment of T corporis.
OBJECTIVES: To compare the efficacy of topical antifungal agents, Sertaconazole and Clotrimazole in Tinea corporispatients. MATERIALS AND METHODS: A total of 60(n=60) patients were included in the study. They were divided into two groups of 30 patients each. First group included patients treated with topical Sertaconazole as test drug whereas the second group constituted patients treated with topical Clotrimazole as standard drug. The patients were advised to apply the drug on affected area twice daily for three weeks. The parameters like erythema, scaling, itching, margins and size of the lesion and KOH mount were taken for the assessment of efficacy. This was an open labelled study and patients were followed up every week for three weeks. RESULTS: The total score included all grades in erythema, itching, scaling, margins and size of lesion and KOH mount. There was significant reduction in erythema (p<0.02) and highly significant reduction in scaling (p<0.001), itching (p<0.001) and margins of lesion (p<0.001) among Sertaconazole group. The mean difference and the standard deviation of total scores for Clotrimazole were 7.20 and 1.69 and for Sertaconazole group 8.80 and 1.52 respectively. The p-value on application of students unpaired t- test was p<0.001 (Highly significant). CONCLUSION: From the present study, it can be concluded that topical Sertaconazole shows better improvement in the clinical parameters than topical Clotrimazole within a span of three weeks in the treatment of T corporis.
Entities:
Keywords:
Antifungal agents; Clotrimazole; Sertaconazole; Tinea corporis
Authors: A J Carrillo-Muñoz; G Quindós; O Del Valle; P Santos; G Giusiano; C Guardia; E Eraso; P A Ezkurra; C Tur-Tur; J M Hernández-Molina Journal: J Chemother Date: 2008-08 Impact factor: 1.714
Authors: A J Carrillo-Muñoz; A Guglietta; C Palacín; J Casals; O del Valle; C Guardià; V Rodríguez; G Quindós Journal: Chemotherapy Date: 2004-12-08 Impact factor: 2.544
Authors: C Alomar; S Bassas; M Casas; V Crespo; C Ferrándiz; E Fonseca; B Hernández; J Noguera; R Pedragosa; J Peyrí Journal: Arzneimittelforschung Date: 1992-05