Joon Young Kim1, Michael I Goran2,3, Claudia M Toledo-Corral2, Marc J Weigensberg4, Gabriel Q Shaibi1,5. 1. Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA. 2. Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA. 3. Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 4. Department of Pediatrics, University of Southern California, Los Angeles, CA, USA. 5. College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA.
Abstract
OBJECTIVE: One hour (1-hr) glucose during an oral glucose tolerance test (OGTT) is an emerging biomarker for type 2 diabetes. We compared the predictive power of 1-hr glucose to traditional glycemic markers for prospectively identifying prediabetes in youth. RESEARCH DESIGN AND METHODS: Obese normoglycemic Latino youth (N = 116) were assessed at baseline for glycated hemoglobin (HbA1c), fasting, 1-hr, and 2-hr glucose during an OGTT and were followed for up to 8 yr for the development of prediabetes. Receiver operating characteristic (ROC) curves were used and a multivariable prediction model was developed. RESULTS: The area under the 1-hr glucose ROC curve was the most powerful predictor of prediabetes over time [0.73, 95% confidence interval (CI) = 0.64-0.83]. However, combining all indicators into a single model was superior to individual marker models (0.77, 95% CI = 0.690.86). CONCLUSIONS: These results further support the utility of 1-hr glucose during an OGTT as a prospective marker of diabetes risk in youth.
OBJECTIVE: One hour (1-hr) glucose during an oral glucose tolerance test (OGTT) is an emerging biomarker for type 2 diabetes. We compared the predictive power of 1-hr glucose to traditional glycemic markers for prospectively identifying prediabetes in youth. RESEARCH DESIGN AND METHODS: Obese normoglycemic Latino youth (N = 116) were assessed at baseline for glycated hemoglobin (HbA1c), fasting, 1-hr, and 2-hr glucose during an OGTT and were followed for up to 8 yr for the development of prediabetes. Receiver operating characteristic (ROC) curves were used and a multivariable prediction model was developed. RESULTS: The area under the 1-hr glucose ROC curve was the most powerful predictor of prediabetes over time [0.73, 95% confidence interval (CI) = 0.64-0.83]. However, combining all indicators into a single model was superior to individual marker models (0.77, 95% CI = 0.690.86). CONCLUSIONS: These results further support the utility of 1-hr glucose during an OGTT as a prospective marker of diabetes risk in youth.
Authors: Christine L Chan; Laura Pyle; Megan M Kelsey; Lindsey Newnes; Amy Baumgartner; Philip S Zeitler; Kristen J Nadeau Journal: Pediatr Diabetes Date: 2016-11-22 Impact factor: 4.866
Authors: Joon Young Kim; Fida Bacha; Hala Tfayli; Sara F Michaliszyn; Shahwar Yousuf; Silva Arslanian Journal: Diabetes Care Date: 2018-11-19 Impact factor: 19.112