Literature DB >> 25385020

Use of intracellular transport processes for targeted drug delivery into a specified cellular compartment.

A A Rosenkranz1, A V Ulasov, T A Slastnikova, Y V Khramtsov, A S Sobolev.   

Abstract

Targeted drug delivery into the cell compartment that is the most vulnerable to effects of the corresponding drug is a challenging problem, and its successful solution can significantly increase the efficiency and reduce side effects of the delivered therapeutic agents. To accomplish this one can utilize natural mechanisms of cellular specific uptake of macromolecules by receptor-mediated endocytosis and intracellular transport between cellular compartments. A transporting construction combining the components responsible for different steps of intracellular transport is promising for creating multifunctional modular constructions capable of delivering the necessary therapeutic agent into a given compartment of type-specified cells. This review focuses on intracellular transport peculiarities along with approaches for designing such transporting constructions for new, more effective, and safer strategies for treatment of various diseases.

Mesh：

Year:  2014        PMID： 25385020     DOI： 10.1134/S0006297914090090

Source DB:  PubMed          Journal:  Biochemistry (Mosc)        ISSN： 0006-2979            Impact factor:   2.487


  6 in total

1.  New Recombinant Carriers Binding Specifically to the Epidermal Growth Factor Receptor.

Authors:  T S Karyagina; A V Ulasov; A A Rosenkranz; T A Slastnikova; Y V Khramtsov; T N Lupanova; G P Georgiev; A S Sobolev
Journal:  Dokl Biochem Biophys       Date:  2020-04-27       Impact factor: 0.788

2.  Cell-penetrating peptide conjugates of gambogic acid enhance the antitumor effect on human bladder cancer EJ cells through ROS-mediated apoptosis.

Authors:  Lei Lyu; Lu-Qi Huang; Tao Huang; Wei Xiang; Jing-Dong Yuan; Chuan-Hua Zhang
Journal:  Drug Des Devel Ther       Date:  2018-04-05       Impact factor: 4.162

3.  Development and evaluation of a new modular nanotransporter for drug delivery into nuclei of pathological cells expressing folate receptors.

Authors:  Tatiana A Slastnikova; Andrey A Rosenkranz; Yuri V Khramtsov; Tatiana S Karyagina; Sergey A Ovechko; Alexander S Sobolev
Journal:  Drug Des Devel Ther       Date:  2017-04-26       Impact factor: 4.162

4.  Preparation, cytotoxicity, and in vivo antitumor efficacy of 111In-labeled modular nanotransporters.

Authors:  Tatiana A Slastnikova; Andrey A Rosenkranz; Natalia B Morozova; Maria S Vorontsova; Vasiliy M Petriev; Tatiana N Lupanova; Alexey V Ulasov; Michael R Zalutsky; Raisa I Yakubovskaya; Alexander S Sobolev
Journal:  Int J Nanomedicine       Date:  2017-01-10

5.  Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression.

Authors:  Andrey A Rosenkranz; Tatiana A Slastnikova; Tatiana A Karmakova; Maria S Vorontsova; Natalia B Morozova; Vasiliy M Petriev; Alexey S Abrosimov; Yuri V Khramtsov; Tatiana N Lupanova; Alexey V Ulasov; Raisa I Yakubovskaya; Georgii P Georgiev; Alexander S Sobolev
Journal:  Front Pharmacol       Date:  2018-11-19       Impact factor: 5.810

6.  Localization and Absolute Quantification of Dopamine in Discrete Intravesicular Compartments Using NanoSIMS Imaging.

Authors:  Stefania Rabasco; Tho D K Nguyen; Chaoyi Gu; Michael E Kurczy; Nhu T N Phan; Andrew G Ewing
Journal:  Int J Mol Sci       Date:  2021-12-23       Impact factor: 5.923
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.