Literature DB >> 25384177

Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts.

Pu-Cha Yan1, Jian-Hua Xie, Xiang-Dong Zhang, Kang Chen, Yuan-Qiang Li, Qi-Lin Zhou, Da-Qing Che.   

Abstract

A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.

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Year:  2014        PMID: 25384177     DOI: 10.1039/c4cc07643e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis.

Authors:  Shuke Wu; Yi Zhou; Tianwen Wang; Heng-Phon Too; Daniel I C Wang; Zhi Li
Journal:  Nat Commun       Date:  2016-06-14       Impact factor: 14.919

  1 in total

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