Hanna M Vesterinen1, Paula I Johnson1,2, Dylan S Atchley1, Patrice Sutton1, Juleen Lam3, Marya G Zlatnik4, Saunak Sen5, Tracey J Woodruff1. 1. a Department of Obstetrics , Gynecology, and Reproductive Sciences, UCSF Program on Reproductive Health and the Environment, University of California , San Francisco , CA , USA . 2. b California Department of Public Health , Occupational Health Branch , Richmond , CA , USA . 3. c Department of Health , Policy and Management, John Hopkins University , Baltimore , MD , USA . 4. d Department of Obstetrics , Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine, UCSF , San Francisco , CA , USA , and. 5. e Department of Epidemiology and Biostatistics , UCSF , San Francisco , CA , USA.
Abstract
OBJECTIVE: Glomerular filtration rate (GFR) may influence concentrations of biomarkers of exposure and their etiologic significance in observational studies of associations between environmental contaminants and fetal growth. It is unknown whether the size of a developing fetus affects maternal GFR such that a small fetus leads to reduced plasma volume expansion (PVE), reduced GFR and subsequent higher concentrations of biomarkers in maternal serum. Our objective was to answer the question: "Is there an association between fetal growth and maternal GFR in humans?" METHODS: We adapted and applied the Navigation Guide systematic review methodology to assess the evidence of an association between fetal growth and GFR, either directly or indirectly via reduction in PVE. RESULTS: We identified 35 relevant studies. We rated 31 human and two non-human observational studies as "low" quality and two experimental non-human studies as "very low" quality. We rated all three evidence streams as "inadequate". The association between fetal growth and GFR was "not classifiable" according to pre-specified definitions. CONCLUSIONS: There is currently insufficient evidence to support the plausibility of a reverse causality hypothesis for associations between exposure to environmental chemicals during pregnancy and fetal growth. Further research would be needed to confirm or disprove this hypothesis.
OBJECTIVE: Glomerular filtration rate (GFR) may influence concentrations of biomarkers of exposure and their etiologic significance in observational studies of associations between environmental contaminants and fetal growth. It is unknown whether the size of a developing fetus affects maternal GFR such that a small fetus leads to reduced plasma volume expansion (PVE), reduced GFR and subsequent higher concentrations of biomarkers in maternal serum. Our objective was to answer the question: "Is there an association between fetal growth and maternal GFR in humans?" METHODS: We adapted and applied the Navigation Guide systematic review methodology to assess the evidence of an association between fetal growth and GFR, either directly or indirectly via reduction in PVE. RESULTS: We identified 35 relevant studies. We rated 31 human and two non-human observational studies as "low" quality and two experimental non-human studies as "very low" quality. We rated all three evidence streams as "inadequate". The association between fetal growth and GFR was "not classifiable" according to pre-specified definitions. CONCLUSIONS: There is currently insufficient evidence to support the plausibility of a reverse causality hypothesis for associations between exposure to environmental chemicals during pregnancy and fetal growth. Further research would be needed to confirm or disprove this hypothesis.
Authors: Jian Li; Frank Pega; Yuka Ujita; Chantal Brisson; Els Clays; Alexis Descatha; Marco M Ferrario; Lode Godderis; Sergio Iavicoli; Paul A Landsbergis; Maria-Inti Metzendorf; Rebecca L Morgan; Daniela V Pachito; Hynek Pikhart; Bernd Richter; Mattia Roncaioli; Reiner Rugulies; Peter L Schnall; Grace Sembajwe; Xavier Trudel; Akizumi Tsutsumi; Tracey J Woodruff; Johannes Siegrist Journal: Environ Int Date: 2020-06-05 Impact factor: 9.621
Authors: Patrice Sutton; Nicholas Chartres; Swati D G Rayasam; Natalyn Daniels; Juleen Lam; Eman Maghrbi; Tracey J Woodruff Journal: Environ Int Date: 2021-03-30 Impact factor: 13.352
Authors: Juleen Lam; Bruce P Lanphear; David Bellinger; Daniel A Axelrad; Jennifer McPartland; Patrice Sutton; Lisette Davidson; Natalyn Daniels; Saunak Sen; Tracey J Woodruff Journal: Environ Health Perspect Date: 2017-08-03 Impact factor: 9.031
Authors: Ana María Mora; Emily Oken; Sheryl L Rifas-Shiman; Thomas F Webster; Matthew W Gillman; Antonia M Calafat; Xiaoyun Ye; Sharon K Sagiv Journal: Environ Health Perspect Date: 2016-06-28 Impact factor: 9.031
Authors: Liliane R Teixeira; Frank Pega; Angel M Dzhambov; Alicja Bortkiewicz; Denise T Correa da Silva; Carlos A F de Andrade; Elzbieta Gadzicka; Kishor Hadkhale; Sergio Iavicoli; Martha S Martínez-Silveira; Małgorzata Pawlaczyk-Łuszczyńska; Bruna M Rondinone; Jadwiga Siedlecka; Antonio Valenti; Diana Gagliardi Journal: Environ Int Date: 2021-02-18 Impact factor: 9.621
Authors: Frank Pega; Nicholas Chartres; Neela Guha; Alberto Modenese; Rebecca L Morgan; Martha S Martínez-Silveira; Dana Loomis Journal: Environ Int Date: 2020-09-17 Impact factor: 9.621