Juan Liu1, Feng Wang2, Songli Shi3. 1. Department of Internal Medicine, Tianjin Union Medicine Center & Tianjin People's Hospital, Tianjin, China. 2. Department of Gerontology, General Hospital of Tianjin Medical University, Tianjin, China. 3. Department of Pathology, Tianjin Union Medicine Center & Tianjin People's Hospital, Tianjin, China.
Abstract
BACKGROUND: Myocardial infarction is a fatal cardiovascular disease and one of the most common death causes all around the world. The aim of the meta-analysis was to quantify the risk of myocardial infarction associated with Helicobacter pylori infection. METHODS: A literature search was performed to identify studies published before 14 July, 2014, for relevant risk estimates. Fixed and random effect meta-analytical techniques were conducted for myocardial infarction. RESULTS: Twenty-six case-control studies involving 5829 myocardial infarction patients and more than 16,000 controls were included. Helicobacter pylori infection was associated with an increased risk of myocardial infarction (OR: 2.10, 95%CI: 1.75-2.53, p = .06). We also discovered a significant association between the bacteria and risk of myocardial infarction in young people (OR: 1.93, 95% CI: 1.41-2.66, p = .07), in elder people (OR: 2.02, 95% CI: 1.60-2.54, p = .29), in Caucasians (OR: 2.29, 95% CI: 1.99-2.63, p = .12), and in Asians (OR: 1.75, 95% CI: 1.12-2.73, p = .08). CONCLUSION: Our meta-analyses suggested a possible indication of relationship between Helicobacter pylori infection and the risk of myocardial infarction. The pathogenicity might not be affected by age and race. More researches should be conducted to explore the mechanisms involved.
BACKGROUND:Myocardial infarction is a fatal cardiovascular disease and one of the most common death causes all around the world. The aim of the meta-analysis was to quantify the risk of myocardial infarction associated with Helicobacter pylori infection. METHODS: A literature search was performed to identify studies published before 14 July, 2014, for relevant risk estimates. Fixed and random effect meta-analytical techniques were conducted for myocardial infarction. RESULTS: Twenty-six case-control studies involving 5829 myocardial infarctionpatients and more than 16,000 controls were included. Helicobacter pylori infection was associated with an increased risk of myocardial infarction (OR: 2.10, 95%CI: 1.75-2.53, p = .06). We also discovered a significant association between the bacteria and risk of myocardial infarction in young people (OR: 1.93, 95% CI: 1.41-2.66, p = .07), in elder people (OR: 2.02, 95% CI: 1.60-2.54, p = .29), in Caucasians (OR: 2.29, 95% CI: 1.99-2.63, p = .12), and in Asians (OR: 1.75, 95% CI: 1.12-2.73, p = .08). CONCLUSION: Our meta-analyses suggested a possible indication of relationship between Helicobacter pylori infection and the risk of myocardial infarction. The pathogenicity might not be affected by age and race. More researches should be conducted to explore the mechanisms involved.
Authors: Jing Yang; Qiang Zhang; Ming Chen; Wu-zhou Wu; Rong Wang; Chang-jun Liu; Bei Li; Xin-li Shi; Han-song Du; Hua-bing Tan Journal: Med Sci Monit Date: 2016-01-12
Authors: Gorm Mørk Hansen; Martin Nilsson; Claus Henrik Nielsen; Palle Holmstrup; Steffen Helqvist; Tim Tolker-Nielsen; Michael Givskov; Peter Riis Hansen Journal: PLoS One Date: 2015-12-22 Impact factor: 3.240