Literature DB >> 25382156

Stereoselective uptake of cell-penetrating peptides is conserved in antisense oligonucleotide polyplexes.

Marco Emanuele Favretto1, Roland Brock.   

Abstract

Stereochemistry matters. A significant conceptual advancement is presented toward the understanding of how functional characteristics of delivery peptides can translate into functional characteristics of peptide-based oligoplexes.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  chirality; drug delivery; endocytosis; gene therapy; oligoplexes

Mesh：

Substances：

Year:  2014        PMID： 25382156     DOI： 10.1002/smll.201402101

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


  2 in total

1.  Advancing peptide siRNA-carrier designs through L/D-amino acid stereochemical modifications to enhance gene silencing.

Authors:  Charles E Holjencin; Colton R Feinberg; Travis Hedrick; Gregory Halsey; Robert D Williams; Priya V Patel; Evan Biles; James C Cummings; Chance Wagner; Naren Vyavahare; Andrew Jakymiw
Journal:  Mol Ther Nucleic Acids       Date:  2021-03-19       Impact factor: 8.886

2.  Delivery of antisense oligonucleotides for splice-correction of androgen receptor pre-mRNA in castration-resistant prostate cancer models using cell-penetrating peptides.

Authors:  Maria V Luna Velez; Omar Paulino da Silva Filho; Gerald W Verhaegh; Onno van Hooij; Najoua El Boujnouni; Roland Brock; Jack A Schalken
Journal:  Prostate       Date:  2022-01-31       Impact factor: 4.012
  2 in total

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