Literature DB >> 2538208

NGF receptor immunoreactivity in aged rat brain.

F Gómez-Pinilla1, C W Cotman, M Nieto-Sampedro.   

Abstract

The cellular distribution of nerve growth factor (NGF) receptor (NGFR) immunoreactivity in 3 cholinergic nuclei (medial septal nucleus, nucleus of the diagonal band and nucleus basalis magnocellularis) of the aged rat brain was compared to that of young-adult animals. In young-adult rats, NGFR immunoreactivity was strong in the neuronal body and in the whole dendritic tree. In aged animals, NGFR immunoreactivity was weak in both cell body and dendrites and was practically absent in the dendrite's distal portion. The loss of dendritic NGFR may play a critical role in the decline of neuronal function in the aging brain.

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Year:  1989        PMID： 2538208     DOI： 10.1016/0006-8993(89)91626-0

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

1.  Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats.

Authors:  Alvin V Terry; Ammar Kutiyanawalla; Anilkumar Pillai
Journal:  Physiol Behav       Date:  2010-11-06

Review 2.  Nerve growth factor and neuronal cell death.

Authors:  J R Perez-Polo; P J Foreman; G R Jackson; D Shan; G Taglialatela; L W Thorpe; K Werrbach-Perez
Journal:  Mol Neurobiol       Date:  1990 Spring-Summer       Impact factor: 5.590

3.  Recombinant human nerve growth factor is biologically active and labels novel high-affinity binding sites in rat brain.

Authors:  C A Altar; L E Burton; G L Bennett; M Dugich-Djordjevic
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-01       Impact factor: 11.205

4.  Efficacy of leukemia inhibitory factor as a therapeutic for permanent large vessel stroke differs among aged male and female rats.

Authors:  Stephanie M Davis; Lisa A Collier; Sarah Goodwin; Douglas E Lukins; David K Powell; Keith R Pennypacker
Journal:  Brain Res       Date:  2018-11-13       Impact factor: 3.252

5.  Age-related decrease of nerve growth factor-like immunoreactivity in the basal forebrain of senescence-accelerated mice.

Authors:  K Ohnishi; H Tomimoto; I Akiguchi; N Seriu; T Kawamata; S Nakamura; J Kimura; T Nishio; K Higuchi; M Hosokawa
Journal:  Acta Neuropathol       Date:  1995       Impact factor: 17.088

6.  Local cerebral glucose utilization in the brain of old, learning impaired rats.

Authors:  A Wree; C Kaever; B Birgel; A Schleicher; E Horvath; K Zilles
Journal:  Histochemistry       Date:  1991
  6 in total

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