Literature DB >> 25381573

Is Cytoplasmic PTEN a Specific Target for Neuronal Survival?

Anand Krishnan1,1, Douglas W Zochodne2,2.   

Abstract

The differential sensitivity of neurons to phosphatase and tensin homolog's (PTEN) lipid and protein phosphatase actions pose difficulties in defining the exact neuronal phenotype generated by targeting PTEN in neuronal injury. PTEN's biology beyond its phosphatase functions are also emerging. Considering spatial dynamics of PTEN a decisive factor for its mode of action we propose selective targeting of its cytoplasmic fraction a better therapeutic approach in neuronal injury.

Entities:  

Keywords:  Akt; Apoptosis; Neuron; PTEN

Mesh：

Substances：

Year:  2014        PMID： 25381573     DOI： 10.1007/s12035-014-8922-3

Source DB:  PubMed          Journal:  Mol Neurobiol        ISSN： 0893-7648            Impact factor:   5.590


  47 in total

1.  A role for nuclear PTEN in neuronal differentiation.

Authors:  M B Lachyankar; N Sultana; C M Schonhoff; P Mitra; W Poluha; S Lambert; P J Quesenberry; N S Litofsky; L D Recht; R Nabi; S J Miller; S Ohta; B G Neel; A H Ross
Journal:  J Neurosci       Date:  2000-02-15       Impact factor: 6.167

Review 2.  Moving past proliferation: new roles for Cdh1-APC in postmitotic neurons.

Authors:  Judith Stegmüller; Azad Bonni
Journal:  Trends Neurosci       Date:  2005-09-15       Impact factor: 13.837

3.  Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner.

Authors:  A Bononi; M Bonora; S Marchi; S Missiroli; F Poletti; C Giorgi; P P Pandolfi; P Pinton
Journal:  Cell Death Differ       Date:  2013-06-28       Impact factor: 15.828

4.  Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke.

Authors:  Baosong Liu; Lijun Li; Quanguang Zhang; Ning Chang; Dianshi Wang; Yuexin Shan; Lei Li; Hanbin Wang; Hua Feng; Liang Zhang; Darrell W Brann; Qi Wan
Journal:  Stroke       Date:  2010-04-01       Impact factor: 7.914

5.  Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.

Authors:  Min Sup Song; Arkaitz Carracedo; Leonardo Salmena; Su Jung Song; Ainara Egia; Marcos Malumbres; Pier Paolo Pandolfi
Journal:  Cell       Date:  2011-01-21       Impact factor: 41.582

6.  PTEN inhibition prevents rat cortical neuron injury after hypoxia-ischemia.

Authors:  J Zhao; Y Qu; J Wu; M Cao; D M Ferriero; L Zhang; D Mu
Journal:  Neuroscience       Date:  2013-03-01       Impact factor: 3.590

7.  Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia.

Authors:  Deyuan Li; Yi Qu; Meng Mao; Xiaolan Zhang; Jinhui Li; Donna Ferriero; Dezhi Mu
Journal:  J Cereb Blood Flow Metab       Date:  2009-07-22       Impact factor: 6.200

Review 8.  The nuclear affairs of PTEN.

Authors:  Sarah M Planchon; Kristin A Waite; Charis Eng
Journal:  J Cell Sci       Date:  2008-02-01       Impact factor: 5.285

9.  Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin.

Authors:  Paola Borgatti; Alberto M Martelli; Giovanna Tabellini; Alfonso Bellacosa; Silvano Capitani; Luca M Neri
Journal:  J Cell Physiol       Date:  2003-07       Impact factor: 6.384

10.  Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia.

Authors:  Jason Howitt; Jenny Lackovic; Ley-Hian Low; Adam Naguib; Alison Macintyre; Choo-Peng Goh; Jennifer K Callaway; Vicki Hammond; Tim Thomas; Matthew Dixon; Ulrich Putz; John Silke; Perry Bartlett; Baoli Yang; Sharad Kumar; Lloyd C Trotman; Seong-Seng Tan
Journal:  J Cell Biol       Date:  2012-01-02       Impact factor: 10.539
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  1 in total

1.  Sympathetic signaling facilitates progression of neuroendocrine prostate cancer.

Authors:  Shubham Dwivedi; Maricris Bautista; Sanskriti Shrestha; Hussain Elhasasna; Tanaya Chaphekar; Frederick S Vizeacoumar; Anand Krishnan
Journal:  Cell Death Discov       Date:  2021-11-22
  1 in total

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