Rikke Gry Secher1, Carsten Rygaard Hjorthøj2, Stephen F Austin3, Anne Thorup4, Pia Jeppesen5, Ole Mors6, Merete Nordentoft4. 1. Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; 2. Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPsych, Aarhus, Denmark; carsten.rygaard.hjorthoej@regionh.dk. 3. Mental Health Center North Zealand, Copenhagen University Hospital, Copenhagen, Denmark; 4. Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPsych, Aarhus, Denmark; 5. Child & Adolescent Mental Health Center, Copenhagen University Hospital, Glostrup, Denmark; 6. The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPsych, Aarhus, Denmark; Research Department P, Aarhus University Hospital, Risskov, Denmark.
Abstract
INTRODUCTION: Specialized early intervention programs such as The Danish OPUS treatment are efficient in treating patients with a first episode of psychosis (FEP) at least after 2 and 5 years. Few studies have examined long-term outcomes of these interventions. AIM: To examine the effect of 2 years of OPUS vs treatment as usual (TAU) within an FEP cohort, 10 years after inclusion into the OPUS trial. METHODS: From 1998 to 2000, participants were randomized to OPUS or TAU. Ten years later, we conducted comprehensive interviews and performed register-based follow-up on all participants in national Danish registers. We analyzed participants according to the intention-to-treat principle. RESULTS: Of the 547 participants included in the study, 347 (63.4%) took part in this follow-up. While there was evidence of a differential 10-year course in the development of negative symptoms, psychiatric bed days, and possibly psychotic symptoms in favor of OPUS treatment, differences were driven by effects at earlier follow-ups and had diminished over time. Statistically significant differences in the course of use of supported housing were present even after 8-10 years. There were no differences between OPUS and TAU regarding income, work-related outcomes, or marital status. CONCLUSION: Most of the positive short-term effects of the OPUS intervention had diminished or vanished at this long-term follow-up. We observed a clear tendency that OPUS treatment leads to fewer days in supported housing. There is a need for further studies investigating if extending the intervention will improve outcomes more markedly at long-term follow-ups.
RCT Entities:
INTRODUCTION: Specialized early intervention programs such as The Danish OPUS treatment are efficient in treating patients with a first episode of psychosis (FEP) at least after 2 and 5 years. Few studies have examined long-term outcomes of these interventions. AIM: To examine the effect of 2 years of OPUS vs treatment as usual (TAU) within an FEP cohort, 10 years after inclusion into the OPUS trial. METHODS: From 1998 to 2000, participants were randomized to OPUS or TAU. Ten years later, we conducted comprehensive interviews and performed register-based follow-up on all participants in national Danish registers. We analyzed participants according to the intention-to-treat principle. RESULTS: Of the 547 participants included in the study, 347 (63.4%) took part in this follow-up. While there was evidence of a differential 10-year course in the development of negative symptoms, psychiatric bed days, and possibly psychotic symptoms in favor of OPUS treatment, differences were driven by effects at earlier follow-ups and had diminished over time. Statistically significant differences in the course of use of supported housing were present even after 8-10 years. There were no differences between OPUS and TAU regarding income, work-related outcomes, or marital status. CONCLUSION: Most of the positive short-term effects of the OPUS intervention had diminished or vanished at this long-term follow-up. We observed a clear tendency that OPUS treatment leads to fewer days in supported housing. There is a need for further studies investigating if extending the intervention will improve outcomes more markedly at long-term follow-ups.
Authors: A Thorup; L Petersen; P Jeppesen; J Ohlenschlaeger; T Christensen; G Krarup; P Jørgensen; M Nordentoft Journal: Schizophr Res Date: 2005-11-01 Impact factor: 4.939
Authors: P Jørgensen; M Nordentoft; M B Abel; G Gouliaev; P Jeppesen; P Kassow Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2000-07 Impact factor: 4.328
Authors: Mette Bertelsen; Pia Jeppesen; Lone Petersen; Anne Thorup; Johan Øhlenschlaeger; Phuong le Quach; Torben Østergaard Christensen; Gertrud Krarup; Per Jørgensen; Merete Nordentoft Journal: Arch Gen Psychiatry Date: 2008-07
Authors: Philippe Conus; Sue Cotton; Benno G Schimmelmann; Patrick D McGorry; Martin Lambert Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2017-05-05 Impact factor: 4.328