Literature DB >> 2538124

Alternative splicing of human insulin receptor messenger RNA.

S Seino1, G I Bell.   

Abstract

The polymerase chain reaction has been used to examine alternative splicing of human insulin receptor (hINSR) mRNA. Alternative splicing of a 36 base pair exon, exon 11, generates hINSR transcripts encoding receptor isoforms which differ in sequence at the C-terminal end of the insulin-binding alpha-subunit. This process appears to be tissue-specific and, in addition, may be developmentally regulated.

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Year:  1989        PMID： 2538124     DOI： 10.1016/0006-291x(89)92439-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  90 in total

1.  Characterization of proliferative effects of insulin, insulin analogues and insulin-like growth factor-1 (IGF-1) in human lung fibroblasts.

Authors:  M Warnken; U Reitzenstein; A Sommer; M Fuhrmann; P Mayer; H Enzmann; U R Juergens; K Racké
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-10-06       Impact factor: 3.000

Review 2.  Hepatic Insulin Clearance: Mechanism and Physiology.

Authors:  Sonia M Najjar; Germán Perdomo
Journal:  Physiology (Bethesda)       Date:  2019-05-01

3.  Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.

Authors:  Sharan Paul; Warunee Dansithong; Dongho Kim; John Rossi; Nicholas J G Webster; Lucio Comai; Sita Reddy
Journal:  EMBO J       Date:  2006-08-31       Impact factor: 11.598

4.  Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A.

Authors:  Alaide Morcavallo; Marco Genua; Angela Palummo; Emilia Kletvikova; Jiri Jiracek; Andrzej M Brzozowski; Renato V Iozzo; Antonino Belfiore; Andrea Morrione
Journal:  J Biol Chem       Date:  2012-02-08       Impact factor: 5.157

5.  Effect of dexamethasone on insulin receptor mRNA levels, RNA stability and isotype RNA pattern in U-937 human promonocytic cells.

Authors:  M A Leal; P Aller; C Calle
Journal:  J Endocrinol Invest       Date:  1996-09       Impact factor: 4.256

6.  Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes.

Authors:  L Mosthaf; J Eriksson; H U Häring; L Groop; E Widen; A Ullrich
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

Review 7.  Misregulation of alternative splicing causes pathogenesis in myotonic dystrophy.

Authors:  N Muge Kuyumcu-Martinez; Thomas A Cooper
Journal:  Prog Mol Subcell Biol       Date:  2006

8.  Regulation of human insulin receptor RNA splicing in vivo.

Authors:  S Norgren; J Zierath; A Wedell; H Wallberg-Henriksson; H Luthman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-15       Impact factor: 11.205

9.  A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.

Authors:  L A Petch; J Harris; V W Raymond; A Blasband; D C Lee; H S Earp
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

Review 10.  Insulin receptor signaling in the development of neuronal structure and function.

Authors:  Shu-Ling Chiu; Hollis T Cline
Journal:  Neural Dev       Date:  2010-03-15       Impact factor: 3.842
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