Literature DB >> 2538108

Interactions of Pseudorabies virus with swine alveolar macrophages I: virus replication.

G Iglesias1, C Pijoan, T Molitor.   

Abstract

The replication of Pseudorabies virus (PRV) in cultured swine alveolar macrophages (AM) was studied using 6 different virus strains. AM were highly permissive to PRV infection, with progeny virus titres of 10(7) TCID50/ml from some strains. Virus progeny titres were higher in cultures infected with the field strains S-62 and 4892 than in cultures infected with the strains Bartha or PRV-C. Virus replication, viral DNA synthesis and the concomitant cell damage were dependent upon virus input m.o.i.s. and virus strain. Furthermore, cells from 7 day old pigs yielded higher virus progeny titres than cells of 6 week old pigs. The results from this study provide support to the premise that PRV infection may predispose anials to respiratory disease.

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Year:  1989        PMID： 2538108     DOI： 10.1007/bf01313812

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  20 in total

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Journal:  J Immunol       Date:  1970-05       Impact factor: 5.422

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Journal:  J Gen Virol       Date:  1985-01       Impact factor: 3.891

9.  Experimental infection of inbred mice with herpes simplex virus. VI. Effect of interferon on in vitro virus replication in macrophages.

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10.  THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS. II. A CELLULAR BASIS FOR THE DEVELOPMENT OF RESISTANCE WITH AGE.

Authors:  R T JOHNSON
Journal:  J Exp Med       Date:  1964-09-01       Impact factor: 14.307
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Review 6.  Rationale for using immunopotentiators in domestic food animals.

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9.  Effects of pseudorabies virus infection upon cytotoxicity and antiviral activities of porcine alveolar macrophages.

Authors:  G Iglesias; C Pijoan; T Molitor
Journal:  Comp Immunol Microbiol Infect Dis       Date:  1992-10       Impact factor: 2.268

Review 10.  Targeting the porcine immune system--particulate vaccines in the 21st century.

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  10 in total

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