PURPOSES: The objective of this study was to test the efficacy of an equine pericardial patch for repairing full-thickness defects of the stomach wall. METHODS: Circular defects, 1.5 cm in diameter, were created on the anterior wall of the stomach of 12 female New Zealand rabbits. The defects were repaired by an equine pericardial patch. After euthanasia at different time intervals (3 days to 8 weeks) a macroscopic evaluation of the abdominal cavity (including adhesion scoring), mechanical testing and a histological examination of the stomach were performed. RESULTS: The animals survived the surgical procedure and underwent an uneventful recovery until euthanasia. None of the patches failed. Adhesions were observed in all animals and were significant in 3/12 animals. Bursting pressure testing indicated that the repair was durable and that adequate strength to prevent patch failure was achieved by the second week. A histological examination showed gradual narrowing of the perforation site by mucosal and limited muscular regeneration. CONCLUSIONS: The equine pericardial patch was successfully used to repair a gastric defect in our experimental model, and it seems that it could have potential as a material suitable for further research concerning the repair of upper gastrointestinal defects.
PURPOSES: The objective of this study was to test the efficacy of an equine pericardial patch for repairing full-thickness defects of the stomach wall. METHODS: Circular defects, 1.5 cm in diameter, were created on the anterior wall of the stomach of 12 female New Zealand rabbits. The defects were repaired by an equine pericardial patch. After euthanasia at different time intervals (3 days to 8 weeks) a macroscopic evaluation of the abdominal cavity (including adhesion scoring), mechanical testing and a histological examination of the stomach were performed. RESULTS: The animals survived the surgical procedure and underwent an uneventful recovery until euthanasia. None of the patches failed. Adhesions were observed in all animals and were significant in 3/12 animals. Bursting pressure testing indicated that the repair was durable and that adequate strength to prevent patch failure was achieved by the second week. A histological examination showed gradual narrowing of the perforation site by mucosal and limited muscular regeneration. CONCLUSIONS: The equine pericardial patch was successfully used to repair a gastric defect in our experimental model, and it seems that it could have potential as a material suitable for further research concerning the repair of upper gastrointestinal defects.
Authors: Matthew J Eckert; Jason T Perry; Vance Y Sohn; Joren B Keylock; Joseph A Munaretto; Alec C Beekley; Matthew J Martin Journal: J Trauma Date: 2009-01
Authors: Tomio Ueno; Sebastian G de la Fuente; Omar I Abdel-Wahab; Toku Takahashi; Marcia Gottfried; Mary B Harris; Makoto Tatewaki; Kenichiro Uemura; D Curtis Lawson; Christopher R Mantyh; Theodore N Pappas Journal: Surgery Date: 2007-09 Impact factor: 3.982
Authors: Daniel A De Ugarte; Edmund Choi; Hal Weitzbuch; Isabella Wulur; Carrie Caulkins; Ben Wu; Eric W Fonkalsrud; James B Atkinson; James C Y Dunn Journal: Am Surg Date: 2004-01 Impact factor: 0.688