Literature DB >> 25379975

An enantioselective total synthesis of Sch-725674.

Kota Ramakrishna1, Krishna P Kaliappan.   

Abstract

An enantioselective total synthesis of Sch-725674, a unique 14-membered macrolactone, has been accomplished in 13 steps. The step-wise dithiane alkylation served as a strategic step to assemble the upper and lower fragments of the molecule, whereas cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction are used as key steps to complete the total synthesis.

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Year:  2015        PMID： 25379975     DOI： 10.1039/c4ob02136c

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  3 in total

1.  A Pot-Economical Approach to the Total Synthesis of Sch-725674.

Authors:  Mahipal Bodugam; Salim Javed; Arghya Ganguly; Jessica Torres; Paul R Hanson
Journal:  Org Lett       Date:  2016-01-13       Impact factor: 6.005

2.  Regio- and Stereoselective Homologation of 1,2-Bis(Boronic Esters): Stereocontrolled Synthesis of 1,3-Diols and Sch 725674.

Authors:  Alexander Fawcett; Dominik Nitsch; Muhammad Ali; Joseph M Bateman; Eddie L Myers; Varinder K Aggarwal
Journal:  Angew Chem Int Ed Engl       Date:  2016-10-26       Impact factor: 15.336

3.  Guiding a divergent reaction by photochemical control: bichromatic selective access to levulinates and butenolides.

Authors:  Revannath L Sutar; Saumik Sen; Or Eivgi; Gal Segalovich; Igor Schapiro; Ofer Reany; N Gabriel Lemcoff
Journal:  Chem Sci       Date:  2017-12-18       Impact factor: 9.825
  3 in total

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