BACKGROUND: Donation after circulatory death is a novel method of increasing the number of donor lungs available for transplantation. Using organs from donors after circulatory death has the potential to increase the number of transplants performed. METHODS: Three bilateral lung transplants from donors after circulatory death were performed over a six-month period. Following organ retrieval, all sets of lungs were placed on a portable ex vivo lung perfusion device for evaluation and preservation. RESULTS: Lung function remained stable during portable ex vivo perfusion, with improvement in partial pressure of oxygen/fraction of inspired oxygen ratios. Mechanical ventilation was discontinued within 48 h for each recipient and no patient stayed in the intensive care unit longer than eight days. There was no postgraft dysfunction at 72 h in two of the three recipients. Ninety-day mortality for all recipients was 0% and all maintain excellent forced expiratory volume in 1 s and forced vital capacity values post-transplantation. CONCLUSION: The authors report excellent results with their initial experience using donors after circulatory death after portable ex vivo lung perfusion. It is hoped this will allow for the most efficient use of available donor lungs, leading to more transplants and fewer deaths for potential recipients on wait lists.
BACKGROUND: Donation after circulatory death is a novel method of increasing the number of donor lungs available for transplantation. Using organs from donors after circulatory death has the potential to increase the number of transplants performed. METHODS: Three bilateral lung transplants from donors after circulatory death were performed over a six-month period. Following organ retrieval, all sets of lungs were placed on a portable ex vivo lung perfusion device for evaluation and preservation. RESULTS: Lung function remained stable during portable ex vivo perfusion, with improvement in partial pressure of oxygen/fraction of inspired oxygen ratios. Mechanical ventilation was discontinued within 48 h for each recipient and no patient stayed in the intensive care unit longer than eight days. There was no postgraft dysfunction at 72 h in two of the three recipients. Ninety-day mortality for all recipients was 0% and all maintain excellent forced expiratory volume in 1 s and forced vital capacity values post-transplantation. CONCLUSION: The authors report excellent results with their initial experience using donors after circulatory death after portable ex vivo lung perfusion. It is hoped this will allow for the most efficient use of available donor lungs, leading to more transplants and fewer deaths for potential recipients on wait lists.
Authors: Tiago N Machuca; Michael K Hsin; Harald C Ott; Manyin Chen; David M Hwang; Marcelo Cypel; Thomas K Waddell; Shaf Keshavjee Journal: Am J Respir Crit Care Med Date: 2013-10-01 Impact factor: 21.405
Authors: Roger D Yusen; Jason D Christie; Leah B Edwards; Anna Y Kucheryavaya; Christian Benden; Anne I Dipchand; Fabienne Dobbels; Richard Kirk; Lars H Lund; Axel O Rahmel; Josef Stehlik Journal: J Heart Lung Transplant Date: 2013-10 Impact factor: 10.247
Authors: Marcelo Cypel; Mingyao Liu; Matt Rubacha; Jonathan C Yeung; Shin Hirayama; Masaki Anraku; Masaaki Sato; Jeffrey Medin; Beverly L Davidson; Marc de Perrot; Thomas K Waddell; Arthur S Slutsky; Shaf Keshavjee Journal: Sci Transl Med Date: 2009-10-28 Impact factor: 17.956
Authors: Jason D Christie; Robert M Kotloff; Vivek N Ahya; Gregory Tino; Alberto Pochettino; Christina Gaughan; Ejigayehu DeMissie; Stephen E Kimmel Journal: Am J Respir Crit Care Med Date: 2005-03-11 Impact factor: 21.405
Authors: Marcelo Cypel; Masaaki Sato; Erkan Yildirim; Wojtek Karolak; Fengshi Chen; Jonathan Yeung; Carlos Boasquevisque; Victoria Leist; Lianne G Singer; Kazuhiro Yasufuku; Marc Deperrot; Thomas K Waddell; Shaf Keshavjee; Andrew Pierre Journal: J Heart Lung Transplant Date: 2009-06-28 Impact factor: 10.247