Literature DB >> 25379595

Preclinical evaluation of the immunomodulatory lymphocyte trafficking drug FTY720 for HIV prevention in the female genital mucosa of macaques.

Monica Morris, Rachael D Aubert, Katherine Butler, Tara Henning, James Mitchell, Leecresia Jenkins, David Garber, Janet McNicholl, Ellen N Kersh.   

Abstract

FTY720 has been shown to reduce inflammatory cytokines and immune cells in the genital mucosa of macaques. This pilot study examined the ability of FTY720 to inhibit HIV acquisition. Systemic treatment with FTY720 failed to prevent or delay vaginal SHIV transmission.

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Year:  2014        PMID： 25379595      PMCID： PMC4225628          DOI： 10.1111/jmp.12120

Source DB:  PubMed          Journal:  J Med Primatol        ISSN： 0047-2565            Impact factor:   0.667


  14 in total

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Authors:  Charles Dobard; Sunita Sharma; Amy Martin; Chou-Pong Pau; Angela Holder; Zsuzsanna Kuklenyik; Jonathan Lipscomb; Debra L Hanson; James Smith; Francis J Novembre; J Gerardo García-Lerma; Walid Heneine
Journal:  J Virol       Date:  2011-11-09       Impact factor: 5.103

Review 2.  Early events in sexual transmission of HIV and SIV and opportunities for interventions.

Authors:  Ashley T Haase
Journal:  Annu Rev Med       Date:  2011       Impact factor: 13.739

Review 3.  Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

Authors:  Volker Brinkmann; Andreas Billich; Thomas Baumruker; Peter Heining; Robert Schmouder; Gordon Francis; Shreeram Aradhye; Pascale Burtin
Journal:  Nat Rev Drug Discov       Date:  2010-10-29       Impact factor: 84.694

4.  AIDS research. Microbicide fails to protect against HIV.

Authors:  Jon Cohen
Journal:  Science       Date:  2008-02-22       Impact factor: 47.728

5.  Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques.

Authors:  Ellen N Kersh; Wei Luo; Debra R Adams; James Mitchell; J Gerardo Garcia-Lerma; Sal Butera; Tom Folks; Ron Otten
Journal:  J Antimicrob Chemother       Date:  2009-02-13       Impact factor: 5.790

6.  The number and distribution of immune cells in the cervicovaginal mucosa remain constant throughout the menstrual cycle of rhesus macaques.

Authors:  Z Ma; F X Lü; M Torten; C J Miller
Journal:  Clin Immunol       Date:  2001-08       Impact factor: 3.969

7.  Immunological microenvironments in the human vagina and cervix: mediators of cellular immunity are concentrated in the cervical transformation zone.

Authors:  Jeffrey Pudney; Alison J Quayle; Deborah J Anderson
Journal:  Biol Reprod       Date:  2005-08-10       Impact factor: 4.285

8.  Chemoprophylaxis with tenofovir disoproxil fumarate provided partial protection against infection with simian human immunodeficiency virus in macaques given multiple virus challenges.

Authors:  Shambavi Subbarao; Ronald A Otten; Artur Ramos; Caryn Kim; Eddie Jackson; Michael Monsour; Debra R Adams; Sheila Bashirian; Jeffrey Johnson; Vincent Soriano; Ana Rendon; Michael G Hudgens; Salvatore Butera; Robert Janssen; Lynn Paxton; Alan E Greenberg; Thomas M Folks
Journal:  J Infect Dis       Date:  2006-08-29       Impact factor: 5.226

9.  Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.

Authors:  Mehrdad Matloubian; Charles G Lo; Guy Cinamon; Matthew J Lesneski; Ying Xu; Volker Brinkmann; Maria L Allende; Richard L Proia; Jason G Cyster
Journal:  Nature       Date:  2004-01-22       Impact factor: 49.962

Review 10.  Assessment of topical microbicides to prevent HIV-1 transmission: concepts, testing, lessons learned.

Authors:  David R Friend; Patrick F Kiser
Journal:  Antiviral Res       Date:  2013-07-08       Impact factor: 5.970
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  3 in total

1.  Chemoattractant-mediated leukocyte trafficking enables HIV dissemination from the genital mucosa.

Authors:  Maud Deruaz; Thomas T Murooka; Sophina Ji; Marc A Gavin; Vladimir D Vrbanac; Judy Lieberman; Andrew M Tager; Thorsten R Mempel; Andrew D Luster
Journal:  JCI Insight       Date:  2017-04-06

2.  Short Communication: Practical Experience with Analysis and Design of Repeat Low-Dose SHIVSF162P3 Exposure Studies in Female Pigtail Macaques with Varying Susceptibility During Menstrual Cycling.

Authors:  Ellen N Kersh; Tara R Henning; Charles Dobard; Walid Heneine; Janet M McNicholl
Journal:  AIDS Res Hum Retroviruses       Date:  2015-08-06       Impact factor: 2.205

Review 3.  Emerging Connections of S1P-Metabolizing Enzymes with Host Defense and Immunity During Virus Infections.

Authors:  Jennifer J Wolf; Caleb J Studstill; Bumsuk Hahm
Journal:  Viruses       Date:  2019-11-27       Impact factor: 5.048
  3 in total

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