| Literature DB >> 2537882 |
E A Emini1, W A Schleif, M Silberklang, D Lehman, R W Ellis.
Abstract
The Epstein-Barr virus (EBV) major membrane antigen, gp350/220, was purified from expressing, genetically engineered Vero cells. The antigen, formulated either with alum or Freund's adjuvant, was inoculated into EBV infection-susceptible marmosets. After several injections, most of the marmosets developed anti-gp350/220 antibodies, and several exhibited virus-neutralizing activity. The immune response elicited by the alum-absorbed antigen proved to be protective upon virus challenge of the inoculated animals. Protection did not correlate with the presence of neutralizing antibodies.Entities:
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Year: 1989 PMID： 2537882 DOI： 10.1002/jmv.1890270210
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327