| Literature DB >> 25378578 |
Jennifer L Lyons1, Kiran T Thakur2, Rick Lee3, Tonya Watkins4, Carlos A Pardo2, Kathryn A Carson5, Barbara Markley6, Malcolm A Finkelman6, Kieren A Marr7, Karen L Roos8, Sean X Zhang9.
Abstract
(1-3)-β-d-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.Entities:
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Year: 2014 PMID: 25378578 PMCID: PMC4290946 DOI: 10.1128/JCM.02301-14
Source DB: PubMed Journal: J Clin Microbiol ISSN: 0095-1137 Impact factor: 5.948