Literature DB >> 25378549

Creating human organs in chimaera pigs: an ethical source of immunocompatible organs?

David Shaw1, Wybo Dondorp2, Niels Geijsen3, Guido de Wert2.   

Abstract

New techniques in regenerative medicine may soon enable the creation of human organs inside animals using induced pluripotent stem cells. This technology has the potential to solve the organ scarcity problem by providing a limitless source of personalised organs for transplantation, but also raises several ethical issues, particularly concerning animal welfare, the 'human features' problem and human dignity. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Entities:  

Keywords:  Animal Production; Genetic Engineering; Stem Cell Research; Transplantation

Mesh：

Year:  2014        PMID： 25378549     DOI： 10.1136/medethics-2014-102224

Source DB:  PubMed          Journal:  J Med Ethics        ISSN： 0306-6800            Impact factor:   2.903


  12 in total

1.  The Japanese Generally Accept Human-Animal Chimeric Embryo Research but Are Concerned About Human Cells Contributing to Brain and Gametes.

Authors:  Tsutomu Sawai; Taichi Hatta; Misao Fujita
Journal:  Stem Cells Transl Med       Date:  2017-07-11       Impact factor: 6.940

Review 2.  Livestock models for exploiting the promise of pluripotent stem cells.

Authors:  R Michael Roberts; Ye Yuan; Nicholas Genovese; Toshihiko Ezashi
Journal:  ILAR J       Date:  2015

Review 3.  Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine.

Authors:  Nozomu Takata; Mototsugu Eiraku
Journal:  J Hum Genet       Date:  2017-10-11       Impact factor: 3.172

Review 4.  The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs.

Authors:  Wanyou Feng; Yifan Dai; Lisha Mou; David K C Cooper; Deshun Shi; Zhiming Cai
Journal:  Int J Mol Sci       Date:  2015-03-23       Impact factor: 5.923

5.  The ethics of killing human/great-ape chimeras for their organs: a reply to Shaw et al.

Authors:  César Palacios-González
Journal:  Med Health Care Philos       Date:  2016-06

Review 6.  Human-animal chimeras: ethical issues about farming chimeric animals bearing human organs.

Authors:  Rodolphe Bourret; Eric Martinez; François Vialla; Chloé Giquel; Aurélie Thonnat-Marin; John De Vos
Journal:  Stem Cell Res Ther       Date:  2016-06-29       Impact factor: 6.832

7.  3D bioprint me: a socioethical view of bioprinting human organs and tissues.

Authors:  Niki Vermeulen; Gill Haddow; Tirion Seymour; Alan Faulkner-Jones; Wenmiao Shu
Journal:  J Med Ethics       Date:  2017-03-20       Impact factor: 2.903

Review 8.  Stem Cell Research and Clinical Translation: A Roadmap about Good Clinical Practice and Patient Care.

Authors:  Paola Frati; Matteo Scopetti; Alessandro Santurro; Vittorio Gatto; Vittorio Fineschi
Journal:  Stem Cells Int       Date:  2017-09-27       Impact factor: 5.443

9.  Moral uncertainty and the farming of human-pig chimeras.

Authors:  Julian Koplin; Dominic Wilkinson
Journal:  J Med Ethics       Date:  2019-06-29       Impact factor: 5.926

10.  Current and emerging global themes in the bioethics of regenerative medicine: the tangled web of stem cell translation.

Authors:  Sarah Chan
Journal:  Regen Med       Date:  2017-11-09       Impact factor: 3.806
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