Literature DB >> 25378111

High-dose tigecycline and colistin for successful treatment of disseminated carbapenem-resistant Klebsiella pneumoniae infection in a liver transplant recipient.

Jennifer Marie Dan1, Michel Henry Mendler2, Alan W Hemming3, Saima Aslam1.   

Abstract

Solid organ transplantation (SOT) is a risk factor for the acquisition of carbapenem-resistant Klebsiella pneumoniae. This infection is associated with a high mortality rate given the limited armamentarium of antibiotics for multidrug-resistant organisms along with continued immunosuppression to prevent graft rejection. We report a case of carbapenem-resistant K. pneumoniae pneumonia, bacteraemia and intra-abdominal infection in a newly transplanted liver recipient. The patient was successfully treated with a long course of high-dose tigecycline and colistin, along with surgical drainage. We discuss SOT-relevant epidemiology, therapeutic options and the rationale for our treatment choice. 2014 BMJ Publishing Group Ltd.

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Year:  2014        PMID： 25378111      PMCID： PMC4225299          DOI： 10.1136/bcr-2014-205865

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  14 in total

1.  Epidemiology and molecular characterization of bacteremia due to carbapenem-resistant Klebsiella pneumoniae in transplant recipients.

Authors:  C J Clancy; L Chen; R K Shields; Y Zhao; S Cheng; K D Chavda; B Hao; J H Hong; Y Doi; E J Kwak; F P Silveira; R Abdel-Massih; T Bogdanovich; A Humar; D S Perlin; B N Kreiswirth; M Hong Nguyen
Journal:  Am J Transplant       Date:  2013-09-06       Impact factor: 8.086

Review 2.  Efficacy and safety of tigecycline: a systematic review and meta-analysis.

Authors:  Dafna Yahav; Adi Lador; Mical Paul; Leonard Leibovici
Journal:  J Antimicrob Chemother       Date:  2011-06-18       Impact factor: 5.790

Review 3.  Predictors of mortality in multidrug-resistant Klebsiella pneumoniae bloodstream infections.

Authors:  Pierluigi Viale; Maddalena Giannella; Russell Lewis; Emanuele Maria Trecarichi; Nicola Petrosillo; Mario Tumbarello
Journal:  Expert Rev Anti Infect Ther       Date:  2013-09-27       Impact factor: 5.091

4.  Mortality associated with carbapenem-resistant Klebsiella pneumoniae infections in liver transplant recipients.

Authors:  Jayant S Kalpoe; Edith Sonnenberg; Stephanie H Factor; Juan del Rio Martin; Thomas Schiano; Gopi Patel; Shirish Huprikar
Journal:  Liver Transpl       Date:  2012-04       Impact factor: 5.799

5.  Predictors of mortality in patients with bloodstream infections caused by KPC-producing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment.

Authors:  O Zarkotou; S Pournaras; P Tselioti; V Dragoumanos; V Pitiriga; K Ranellou; A Prekates; K Themeli-Digalaki; A Tsakris
Journal:  Clin Microbiol Infect       Date:  2011-05-20       Impact factor: 8.067

6.  Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies.

Authors:  Gopi Patel; Shirish Huprikar; Stephanie H Factor; Stephen G Jenkins; David P Calfee
Journal:  Infect Control Hosp Epidemiol       Date:  2008-12       Impact factor: 3.254

7.  Fatal cross infection by carbapenem-resistant Klebsiella in two liver transplant recipients.

Authors:  A J Mathers; H L Cox; H Bonatti; B Kitchel; A K C Brassinga; B Wispelwey; R G Sawyer; T L Pruett; K C Hazen; J B Patel; C D Sifri
Journal:  Transpl Infect Dis       Date:  2009-02-18       Impact factor: 2.228

Review 8.  Treatment of Klebsiella pneumoniae carbapenemase (KPC) infections: a review of published case series and case reports.

Authors:  Grace C Lee; David S Burgess
Journal:  Ann Clin Microbiol Antimicrob       Date:  2012-12-13       Impact factor: 3.944

9.  KPC - 3 Klebsiella pneumoniae ST258 clone infection in postoperative abdominal surgery patients in an intensive care setting: analysis of a case series of 30 patients.

Authors:  Paola Di Carlo; Gaspare Gulotta; Alessandra Casuccio; Gianni Pantuso; Maurizio Raineri; Clizia Airò Farulla; Sebastiano Bonventre; Giuliana Guadagnino; Daniela Ingrassia; Gianfranco Cocorullo; Caterina Mammina; Antonino Giarratano
Journal:  BMC Anesthesiol       Date:  2013-07-03       Impact factor: 2.217

10.  Colistin: recent data on pharmacodynamics properties and clinical efficacy in critically ill patients.

Authors:  Argyris S Michalopoulos; Matthew E Falagas
Journal:  Ann Intensive Care       Date:  2011-08-02       Impact factor: 6.925
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  1 in total

1.  Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria.

Authors:  Phillip J Bergen; Zackery P Bulman; Cornelia B Landersdorfer; Nicholas Smith; Justin R Lenhard; Jürgen B Bulitta; Roger L Nation; Jian Li; Brian T Tsuji
Journal:  Infect Dis Ther       Date:  2015-12-08
  1 in total

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