Literature DB >> 25377988

The Gateway Hypothesis of substance abuse: developmental, biological and societal perspectives.

Denise Kandel1, Eric Kandel.   

Abstract

UNLABELLED: The Gateway Hypothesis describes how tobacco or alcohol use precedes marijuana and other illicit drug use. We review the epidemiological data, explore the underlying molecular mechanisms in mice and discuss the societal implications of the hypothesis, including the use of e-cigarettes by young people.
CONCLUSION: Our mouse model identifies biological processes underlying the hypothesis, showing that nicotine is a gateway drug that exerts a priming effect on cocaine through increased global acetylation in the striatum. ©2014 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  Cocaine; E-cigarettes; Gateway Hypothesis; Histone acetylation; Nicotine

Mesh：

Substances：

Year:  2014        PMID： 25377988     DOI： 10.1111/apa.12851

Source DB:  PubMed          Journal:  Acta Paediatr        ISSN： 0803-5253            Impact factor:   2.299


  67 in total

1.  Onset, Comorbidity, and Predictors of Nicotine, Alcohol, and Marijuana Use Disorders Among North American Indigenous Adolescents.

Authors:  Dane Hautala; Kelley Sittner; Melissa Walls
Journal:  J Abnorm Child Psychol       Date:  2019-06

2.  Historical trends in the grade of onset and sequence of cigarette, alcohol, and marijuana use among adolescents from 1976-2016: Implications for "Gateway" patterns in adolescence.

Authors:  Katherine M Keyes; Caroline Rutherford; Richard Miech
Journal:  Drug Alcohol Depend       Date:  2018-10-24       Impact factor: 4.492

3.  Assessing the longitudinal stability of latent classes of substance use among gay, bisexual, and other men who have sex with men.

Authors:  Kiffer G Card; Heather L Armstrong; Allison Carter; Zishan Cui; Lu Wang; Julia Zhu; Nathan J Lachowsky; David M Moore; Robert S Hogg; Eric A Roth
Journal:  Drug Alcohol Depend       Date:  2018-05-22       Impact factor: 4.492

4.  The E-cigarette Social Environment, E-cigarette Use, and Susceptibility to Cigarette Smoking.

Authors:  Jessica L Barrington-Trimis; Kiros Berhane; Jennifer B Unger; Tess Boley Cruz; Robert Urman; Chih Ping Chou; Steve Howland; Kejia Wang; Mary Ann Pentz; Tamika D Gilreath; Jimi Huh; Adam M Leventhal; Jonathan M Samet; Rob McConnell
Journal:  J Adolesc Health       Date:  2016-05-06       Impact factor: 5.012

5.  TrendBlendz: how Splitarillos use marijuana flavours to promote cigarillo use.

Authors:  Ganna Kostygina; Jidong Huang; Sherry Emery
Journal:  Tob Control       Date:  2016-04-06       Impact factor: 7.552

6.  Treating Smoking in Adults With Co-occurring Acute Psychiatric and Addictive Disorders.

Authors:  Smita Das; Norval J Hickman; Judith J Prochaska
Journal:  J Addict Med       Date:  2017 Jul/Aug       Impact factor: 3.702

7.  The Effects of Marijuana Use on Transitions through Stages of Alcohol Involvement for Men and Women in the NESARC I and II.

Authors:  Kerry M Green; Beth A Reboussin; Lauren R Pacek; Carla L Storr; Ramin Mojtabai; Bernadette A Cullen; Rosa M Crum
Journal:  Subst Use Misuse       Date:  2019-07-12       Impact factor: 2.164

8.  The social exigencies of the gateway progression to the use of illicit drugs from adolescence into adulthood.

Authors:  Roy Otten; Chung Jung Mun; Thomas J Dishion
Journal:  Addict Behav       Date:  2017-05-11       Impact factor: 3.913

9.  Patterns of youth tobacco and polytobacco usage: The shift to alternative tobacco products.

Authors:  Paul T Harrell; Syeda Mahrukh Hussnain Naqvi; Andrew D Plunk; Ming Ji; Silvia S Martins
Journal:  Am J Drug Alcohol Abuse       Date:  2016-09-26       Impact factor: 3.829

10.  Longitudinal associations between youth tobacco and substance use in waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study.

Authors:  Marushka L Silveira; Kevin P Conway; Victoria R Green; Karin A Kasza; James D Sargent; Nicolette Borek; Cassandra A Stanton; Amy Cohn; Nahla Hilmi; K Michael Cummings; Raymond S Niaura; Elizabeth Y Lambert; Mary F Brunette; Izabella Zandberg; Susanne E Tanski; Chad J Reissig; Priscilla Callahan-Lyon; Wendy I Slavit; Andrew J Hyland; Wilson M Compton
Journal:  Drug Alcohol Depend       Date:  2018-07-25       Impact factor: 4.492
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