Literature DB >> 2537741

Cyclic nucleotide elevating vasodilators inhibit platelet aggregation at an early step of the activation cascade.

R Waldmann1, U Walter.   

Abstract

The mechanism of vasodilator-induced inhibition of platelet aggregation was investigated in human platelets. Cyclic nucleotide-elevating vasodilators stimulated cAMP- or cGMP-dependent protein phosphorylation, inhibited the activation of both protein kinase C and myosin light chain kinase, and inhibited the thrombin-induced hydrolysis of phosphatidylinositol-4,5-bisphosphate without affecting its resynthesis. The results suggest that cAMP- and cGMP-elevating vasodilators both inhibit platelet aggregation at an early step of the activation cascade, presumably at the level of phospholipase C.

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Year:  1989        PMID： 2537741     DOI： 10.1016/0014-2999(89)90165-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

Review 1.  Signal transduction by cGMP in heart.

Authors:  S M Lohmann; R Fischmeister; U Walter
Journal:  Basic Res Cardiol       Date:  1991 Nov-Dec       Impact factor: 17.165

2.  Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase.

Authors:  G R Wang; Y Zhu; P V Halushka; T M Lincoln; M E Mendelsohn
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

Review 3.  The cGMP-dependent protein kinase--gene, protein, and function.

Authors:  E Butt; J Geiger; T Jarchau; S M Lohmann; U Walter
Journal:  Neurochem Res       Date:  1993-01       Impact factor: 3.996

4.  The use of oxyhaemoglobin to explore the events underlying inhibition of platelet aggregation induced by NO or NO-donors.

Authors:  D Salvemini; W Radziszewski; R Korbut; J Vane
Journal:  Br J Pharmacol       Date:  1990-12       Impact factor: 8.739

5.  Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system.

Authors:  Evanthia Mergia; Andreas Friebe; Oliver Dangel; Michael Russwurm; Doris Koesling
Journal:  J Clin Invest       Date:  2006-05-04       Impact factor: 14.808

6.  Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.

Authors:  J Geiger; C Nolte; E Butt; S O Sage; U Walter
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-01       Impact factor: 11.205

7.  Cyclic nucleotides attenuate thrombin-evoked alterations in parameters of platelet Na/H antiport. The role of cytosolic Ca.

Authors:  M Kimura; N Lasker; A Aviv
Journal:  J Clin Invest       Date:  1992-04       Impact factor: 14.808

8.  The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins.

Authors:  M Reinhard; K Giehl; K Abel; C Haffner; T Jarchau; V Hoppe; B M Jockusch; U Walter
Journal:  EMBO J       Date:  1995-04-18       Impact factor: 11.598

Review 9.  Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy.

Authors:  Rebecca B Knowles; Timothy D Warner
Journal:  Pharmacol Ther       Date:  2018-08-04       Impact factor: 12.310
  9 in total

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