Yong-Jun Wang1, Yu-Tao Yang2, Hui Li2, Po-Zi Liu3, Chuan-Yue Wang4, Zhi-Qing David Xu2. 1. Tianjin AnDing Hospital, Capital Medical University, Beijing Tsinghua University, Beijing. 2. Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University. 3. Tsinghua University, Beijing. 4. Beijing Key Laboratory of Mental Disorders, Capital Medical University.
Abstract
OBJECTIVE: This study investigated the association between plasma galanin level and depression severity. METHODS: The severity of depression symptoms of 79 patients with major depressive disorder (MDD; 52 women and 27 men, 71 patients in onset, 8 in remission) was assessed using the 17-item Hamilton Depression Rating Scale. Venous fasting blood samples (5 mL) were taken from the 79 MDD patients, 35 healthy siblings, and 19 healthy controls, and plasma samples were prepared. Galanin levels in the plasma were measured by radioimmunoassay. RESULTS: Plasma galanin in MDD patients was significantly higher than that of remission patients, healthy siblings, or healthy controls (P < 0.05) There was no significant difference between the healthy sibling and healthy control groups (P = 0.924). Plasma galanin of remission patients was also significantly higher than that of healthy controls (P < 0.05). There was no significant correlation between age and galanin levels in the 79 patients (r = 0.053, P = 0.646), nor was there a correlation between age and galanin levels when patients were stratified by gender (P > 0.05). There was a significant positive correlation between plasma galanin levels and depression severity in women MDD patients (r = 0.329, df = 42, P = 0.020), but not in men patients. CONCLUSIONS: Plasma galanin levels may be an important biomarker for depression severity, especially in female patients.
OBJECTIVE: This study investigated the association between plasma galanin level and depression severity. METHODS: The severity of depression symptoms of 79 patients with major depressive disorder (MDD; 52 women and 27 men, 71 patients in onset, 8 in remission) was assessed using the 17-item Hamilton Depression Rating Scale. Venous fasting blood samples (5 mL) were taken from the 79 MDDpatients, 35 healthy siblings, and 19 healthy controls, and plasma samples were prepared. Galanin levels in the plasma were measured by radioimmunoassay. RESULTS: Plasma galanin in MDDpatients was significantly higher than that of remission patients, healthy siblings, or healthy controls (P < 0.05) There was no significant difference between the healthy sibling and healthy control groups (P = 0.924). Plasma galanin of remission patients was also significantly higher than that of healthy controls (P < 0.05). There was no significant correlation between age and galanin levels in the 79 patients (r = 0.053, P = 0.646), nor was there a correlation between age and galanin levels when patients were stratified by gender (P > 0.05). There was a significant positive correlation between plasma galanin levels and depression severity in womenMDDpatients (r = 0.329, df = 42, P = 0.020), but not in menpatients. CONCLUSIONS: Plasma galanin levels may be an important biomarker for depression severity, especially in female patients.
Entities:
Keywords:
Hamilton Depression Rating Scale; galanin; major depressive disorder; plasma
Authors: Khaled Saad; Ahmed A Abdel-Rahman; Abdulrahman A Al-Atram; Alam-Eldin M Abdallah; Amira Elhoufey; Eman M Nagiub Abdelsalam; Dalia A Nigm; Ola Elshora; Ahmad Roshdy Ahmad; Mohamed M El-Tellawy; Khaled Hashim Mahmoud Journal: Child Psychiatry Hum Dev Date: 2021-02-03