BACKGROUND: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological data in hemodialyzed patients (HD), notably parathormone (PTH), biomarkers of bone turnover, vascular calcifications and mortality after 2 years. METHODS: 164 HD patients were included in this observational study. The calcification score was assessed with the Kauppila method. Patients were followed for 2 years. RESULTS: Median sclerostin levels were significantly (p < 0.0001) higher in HD versus healthy subjects (n = 94) (1,375 vs. 565 pg/ml, respectively). In univariate analysis a significant association (p < 0.05) was found between sclerostin and age, height, dialysis vintage, albumin, troponin, homocysteine, PTH, C-terminal telopeptide of collagen type I, bone-specific alkaline phosphatase and osteoprotegerin, but not with the calcification score. In a multivariate model, the association remained with age, height, dialysis vintage, troponin, homocysteine, phosphate, PTH, but also with vascular calcifications. Association was positive for all variables, except PTH and vascular calcifications. The baseline sclerostin concentration was not different in survivors and non-survivors. CONCLUSIONS: We confirm a higher concentration of sclerostin in HD patients, a positive association with age and a negative association with PTH. A positive association with phosphate, homocysteine and troponin calls for additional research. The clinical interest of sclerostin to assess vascular calcifications in HD is limited and no association was found between sclerostin and mortality.
BACKGROUND: Sclerostin is a potent inhibitor of bone formation, but the meaning of its serum levels remains undetermined. We evaluated the association between sclerostin levels and clinical or biological data in hemodialyzed patients (HD), notably parathormone (PTH), biomarkers of bone turnover, vascular calcifications and mortality after 2 years. METHODS: 164 HDpatients were included in this observational study. The calcification score was assessed with the Kauppila method. Patients were followed for 2 years. RESULTS: Median sclerostin levels were significantly (p < 0.0001) higher in HD versus healthy subjects (n = 94) (1,375 vs. 565 pg/ml, respectively). In univariate analysis a significant association (p < 0.05) was found between sclerostin and age, height, dialysis vintage, albumin, troponin, homocysteine, PTH, C-terminal telopeptide of collagen type I, bone-specific alkaline phosphatase and osteoprotegerin, but not with the calcification score. In a multivariate model, the association remained with age, height, dialysis vintage, troponin, homocysteine, phosphate, PTH, but also with vascular calcifications. Association was positive for all variables, except PTH and vascular calcifications. The baseline sclerostin concentration was not different in survivors and non-survivors. CONCLUSIONS: We confirm a higher concentration of sclerostin in HDpatients, a positive association with age and a negative association with PTH. A positive association with phosphate, homocysteine and troponin calls for additional research. The clinical interest of sclerostin to assess vascular calcifications in HD is limited and no association was found between sclerostin and mortality.
Authors: Rosa M A Moysés; Sophie A Jamal; Fabiana G Graciolli; Luciene M dos Reis; Rosilene M Elias Journal: Int Urol Nephrol Date: 2015-04-11 Impact factor: 2.370
Authors: Abdul Rashid Qureshi; Hannes Olauson; Anna Witasp; Mathias Haarhaus; Vincent Brandenburg; Annika Wernerson; Bengt Lindholm; Magnus Söderberg; Lars Wennberg; Louise Nordfors; Jonaz Ripsweden; Peter Barany; Peter Stenvinkel Journal: Kidney Int Date: 2015-09-02 Impact factor: 10.612
Authors: Thor Ueland; Elisabeth Astrup; Kari Otterdal; Tove Lekva; Jeshina Janardhanan; John A J Prakash; Kurien Thomas; Annika E Michelsen; Pål Aukrust; George M Varghese; Jan K Damås Journal: PLoS Negl Trop Dis Date: 2021-04-29