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Literature DB >> 2537626

Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors.

A L Willcocks¹, J Strupish, R F Irvine, S R Nahorski.

Abstract

The activity of inositol 2,4,5-trisphosphate and inositol 1:2-cyclic,4,5-trisphosphate relative to inositol 1,4,5-trisphosphate was examined by two assays; firstly, in a binding assay using rat cerebellar membranes, and secondly, in a Ca2+-mobilization assay using permeabilized Swiss 3T3 cells. In both assays the first two phosphates have a potency at least an order of magnitude less than inositol 1,4,5-trisphosphate. The possible reasons for differences between these results and previous data are discussed, as are the implications for any putative physiological role for the cyclic trisphosphate.

Entities: Chemical Species

Mesh：

Substances：

Year: 1989 PMID： 2537626 PMCID： PMC1135573 DOI： 10.1042/bj2570297

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

30 in total

Review 1. Inositol phosphates: proliferation, metabolism and function.

Authors: R F Irvine; R M Moor; W K Pollock; P M Smith; K A Wreggett
Journal: Philos Trans R Soc Lond B Biol Sci Date: 1988-07-26 Impact factor: 6.237

Review 2. The role of protein kinase C in cell surface signal transduction and tumour promotion.

Authors: Y Nishizuka
Journal: Nature Date: 1984 Apr 19-25 Impact factor: 49.962

3. Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts.

Authors: T M Connolly; D B Wilson; T E Bross; P W Majerus
Journal: J Biol Chem Date: 1986-01-05 Impact factor: 5.157

4. A saturable receptor for 32P-inositol-1,4,5-triphosphate in hepatocytes and neutrophils.

Authors: A Spät; P G Bradford; J S McKinney; R P Rubin; J W Putney
Journal: Nature Date: 1986 Feb 6-12 Impact factor: 49.962

5. The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues.

Authors: R F Irvine; A J Letcher; J P Heslop; M J Berridge
Journal: Nature Date: 1986 Apr 17-23 Impact factor: 49.962

Review 6. Inositol trisphosphate, a novel second messenger in cellular signal transduction.

Authors: M J Berridge; R F Irvine
Journal: Nature Date: 1984 Nov 22-28 Impact factor: 49.962

7. Binding sites for inositol trisphosphate in the bovine adrenal cortex.

Authors: A J Baukal; G Guillemette; R Rubin; A Spät; K J Catt
Journal: Biochem Biophys Res Commun Date: 1985-12-17 Impact factor: 3.575

8. Binding of inositol trisphosphate by a liver microsomal fraction.

Authors: A Spät; A Fabiato; R P Rubin
Journal: Biochem J Date: 1986-02-01 Impact factor: 3.857

9. Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

Authors: D B Wilson; T M Connolly; T E Bross; P W Majerus; W R Sherman; A N Tyler; L J Rubin; J E Brown
Journal: J Biol Chem Date: 1985-11-05 Impact factor: 5.157

Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptors.

Review 1. Inositol phosphates: proliferation, metabolism and function.

Review 2. The role of protein kinase C in cell surface signal transduction and tumour promotion.

3. Isolation and characterization of the inositol cyclic phosphate products of phosphoinositide cleavage by phospholipase C. Metabolism in cell-free extracts.

4. A saturable receptor for 32P-inositol-1,4,5-triphosphate in hepatocytes and neutrophils.

5. The inositol tris/tetrakisphosphate pathway--demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues.

Review 6. Inositol trisphosphate, a novel second messenger in cellular signal transduction.

7. Binding sites for inositol trisphosphate in the bovine adrenal cortex.

8. Binding of inositol trisphosphate by a liver microsomal fraction.

9. Isolation and characterization of the inositol cyclic phosphate products of polyphosphoinositide cleavage by phospholipase C. Physiological effects in permeabilized platelets and Limulus photoreceptor cells.

10. Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands.

Review 1. Metabolism of the inositol phosphates produced upon receptor activation.

2. Inositol trisphosphate analogues induce different oscillatory patterns in Xenopus oocytes.

3. The Ins(1,4,5)P3 binding site of bovine adrenocortical microsomes: function and regulation.

4. The interrelationships of the inositol phosphates formed in vasopressin-stimulated WRK-1 rat mammary tumour cells.