RATIONALE: Neurocognitive impairments are associated with reduced quality of life and may adversely affect medical compliance, but their prevalence after lung transplantation has not been extensively studied. OBJECTIVES: To examine the frequency of neurocognitive impairment after lung transplantation and to examine perioperative factors affecting post-transplant neurocognitive function. MEASUREMENTS AND MAIN RESULTS: We performed serial assessments of neurocognitive function in a consecutive series of 47 subjects who received transplants between March 2013 and November 2013 (45% women; mean age, 53.5 ± 17.2 yr). Neurocognitive function was assessed using a composite measure including the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total score and Trail Making Test parts A and B obtained before transplant, at hospital discharge, and 3 months after discharge. The presence of neurocognitive impairment was assessed using the Montreal Cognitive Assessment Battery (MoCA), and in-hospital delirium was assessed using the Confusion Assessment Method. Results demonstrated that neurocognitive performance initially worsened among non-cystic fibrosis patients and improved over follow-up (P = 0.002). Time effects were strongest on Trail Making Test part B (P < 0.001) and the RBANS (P = 0.054). Participants who exhibited delirium during their hospitalization showed poorer performance during follow-up assessments (P = 0.006). Examination of cognitive impairment rates demonstrated that 21 participants (45%) exhibited neurocognitive impairment (MoCA < 26) before lung transplant, whereas 27 (57%) participants exhibited impairment after transplantation, and 19 (57%) participants continued to neurocognitive impairment during a 3-month follow-up. CONCLUSIONS: Neurocognitive impairments are prevalent among lung transplant candidates and appear to worsen in some patients after transplant. Delirium during hospitalization is associated with worse neurocognitive function after transplant among patients without cystic fibrosis.
RATIONALE: Neurocognitive impairments are associated with reduced quality of life and may adversely affect medical compliance, but their prevalence after lung transplantation has not been extensively studied. OBJECTIVES: To examine the frequency of neurocognitive impairment after lung transplantation and to examine perioperative factors affecting post-transplant neurocognitive function. MEASUREMENTS AND MAIN RESULTS: We performed serial assessments of neurocognitive function in a consecutive series of 47 subjects who received transplants between March 2013 and November 2013 (45% women; mean age, 53.5 ± 17.2 yr). Neurocognitive function was assessed using a composite measure including the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) total score and Trail Making Test parts A and B obtained before transplant, at hospital discharge, and 3 months after discharge. The presence of neurocognitive impairment was assessed using the Montreal Cognitive Assessment Battery (MoCA), and in-hospital delirium was assessed using the Confusion Assessment Method. Results demonstrated that neurocognitive performance initially worsened among non-cystic fibrosispatients and improved over follow-up (P = 0.002). Time effects were strongest on Trail Making Test part B (P < 0.001) and the RBANS (P = 0.054). Participants who exhibited delirium during their hospitalization showed poorer performance during follow-up assessments (P = 0.006). Examination of cognitive impairment rates demonstrated that 21 participants (45%) exhibited neurocognitive impairment (MoCA < 26) before lung transplant, whereas 27 (57%) participants exhibited impairment after transplantation, and 19 (57%) participants continued to neurocognitive impairment during a 3-month follow-up. CONCLUSIONS:Neurocognitive impairments are prevalent among lung transplant candidates and appear to worsen in some patients after transplant. Delirium during hospitalization is associated with worse neurocognitive function after transplant among patients without cystic fibrosis.
Authors: Priti I Parekh; James A Blumenthal; Michael A Babyak; Rick LaCaille; Sarah Rowe; Liz Dancel; Robert M Carney; R Duane Davis; Scott Palmer Journal: Psychosom Med Date: 2005 May-Jun Impact factor: 4.312
Authors: Jason D Christie; Leah B Edwards; Anna Y Kucheryavaya; Christian Benden; Anne I Dipchand; Fabienne Dobbels; Richard Kirk; Axel O Rahmel; Josef Stehlik; Marshall I Hertz Journal: J Heart Lung Transplant Date: 2012-10 Impact factor: 10.247
Authors: B M Hoffman; J A Blumenthal; R C Carney; C V F O'Hayer; K Freedland; P J Smith; M A Babyak; R D Davis; J P Mathew; T Martinu; S Palmer Journal: Am J Transplant Date: 2012-04-30 Impact factor: 8.086
Authors: Mark L Ettenhofer; Charles H Hinkin; Steven A Castellon; Ramani Durvasula; Jodi Ullman; Mona Lam; Hector Myers; Matthew J Wright; Jessica Foley Journal: Am J Geriatr Psychiatry Date: 2009-04 Impact factor: 4.105
Authors: J P Singer; P P Katz; A Soong; P Shrestha; D Huang; J Ho; M Mindo; J R Greenland; S R Hays; J Golden; J Kukreja; M E Kleinhenz; R J Shah; P D Blanc Journal: Am J Transplant Date: 2017-01-03 Impact factor: 8.086
Authors: Nicholas A Kolaitis; Allison Soong; Pavan Shrestha; Hanjing Zhuo; John Neuhaus; Patti P Katz; John R Greenland; Jeffrey Golden; Lorriana E Leard; Rupal J Shah; Steven R Hays; Jasleen Kukreja; Mary Ellen Kleinhenz; Paul D Blanc; Jonathan P Singer Journal: J Thorac Cardiovasc Surg Date: 2018-02-22 Impact factor: 5.209
Authors: Patrick J Smith; James A Blumenthal; Benson M Hoffman; Sarah K Rivelli; Scott M Palmer; Robert D Davis; Joseph P Mathew Journal: Ann Am Thorac Soc Date: 2016-02
Authors: Jonathan P Singer; Allison Soong; Joan Chen; Pavan Shrestha; Hanjing Zhuo; Ying Gao; John R Greenland; Steven R Hays; Jasleen Kukreja; Jeffrey Golden; Steven E Gregorich; Anita L Stewart Journal: Am J Respir Crit Care Med Date: 2019-04-15 Impact factor: 21.405
Authors: Brian J Anderson; Christopher F Chesley; Miranda Theodore; Colin Christie; Ryan Tino; Alex Wysoczanski; Kristy Ramphal; Michelle Oyster; Laurel Kalman; Mary K Porteous; Christian A Bermudez; Edward Cantu; Dennis L Kolson; Jason D Christie; Joshua M Diamond Journal: J Heart Lung Transplant Date: 2018-02-02 Impact factor: 10.247