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Literature DB >> 25374763

Utilization of Multiphoton Imaging For Real-Time Fate Determination of Mesenchymal Stem Cells in an Immunocompetent Mouse Model.

Jay T Myers¹, Agne Petrosiute², Alex Y Huang².

Abstract

The clinical application of Mesenchymal Stem Cells (MSCs) for the treatment of a variety of diseases is the focus of intense research. Despite large research efforts many questions regarding MSC biology in vivo remain unanswered. For instance, we do not know for certain whether MSCs exert their therapeutic effects directly within the target tissue or indirectly by influencing the polarization of other cell types, such as macrophages, which can then home to the target tissue microenvironment. To help address this issue, the application of intravital multiphoton microscopy allows for the determination of the dynamic action of intact MSCs versus endogenous host cells at the target tissue site in real time.

Entities: Chemical Disease Gene Species

Keywords: Granulocyte; Intravital; MSC; Mesenchymal Stem Cell; Mouse Model; Multiphoton

Year: 2014 PMID： 25374763 PMCID： PMC4218747 DOI： 10.4172/2157-7633.1000217

Source DB: PubMed Journal: J Stem Cell Res Ther

27 in total

1. Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy.

Authors: Liang Leng; Yuebing Wang; Ningning He; Di Wang; Qianjie Zhao; Guowei Feng; Weijun Su; Yang Xu; Zhongchao Han; Deling Kong; Zhen Cheng; Rong Xiang; Zongjin Li
Journal: Biomaterials Date: 2014-03-29 Impact factor: 12.479

2. Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity.

Authors: Junxia Lei; Zhen Wang; Dayang Hui; Weihua Yu; Dunhua Zhou; Wenjie Xia; Chun Chen; Qunzhou Zhang; Zhichong Wang; Qi Zhang; Andy Peng Xiang
Journal: Cell Immunol Date: 2011-06-23 Impact factor: 4.868

3. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes.

Authors: Anna Krasnodembskaya; Gianluca Samarani; Yuanlin Song; Hanjing Zhuo; Xiao Su; Jae-Woo Lee; Naveen Gupta; Mario Petrini; Michael A Matthay
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2012-03-16 Impact factor: 5.464

4. Paracrine effects of mesenchymal stem cells enhance vascular regeneration in ischemic murine skin.

Authors: Stefan Schlosser; Cyrill Dennler; Riccardo Schweizer; Daniel Eberli; Jens V Stein; Volker Enzmann; Pietro Giovanoli; Dominique Erni; Jan A Plock
Journal: Microvasc Res Date: 2012-02-25 Impact factor: 3.514

5. Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting.

Authors: Alma J Nauta; Geert Westerhuis; Alwine B Kruisselbrink; Ellie G A Lurvink; Roel Willemze; Willem E Fibbe
Journal: Blood Date: 2006-05-11 Impact factor: 22.113

6. A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an Immunosuppressive MSC2 phenotype.

Authors: Ruth S Waterman; Suzanne L Tomchuck; Sarah L Henkle; Aline M Betancourt
Journal: PLoS One Date: 2010-04-26 Impact factor: 3.240

7. Optimizing reporter constructs for in vivo bioluminescence imaging of interferon-γ stimulated mesenchymal stromal cells.

Authors: Jorge Perez-Galarza; Françoise Carlotti; Martijn J Rabelink; Steve Cramer; Rob C Hoeben; Willem E Fibbe; Melissa van Pel
Journal: Exp Hematol Date: 2014-04-15 Impact factor: 3.084

Review 1. Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging.

Authors: Nirilanto Ramamonjisoa; Ellen Ackerstaff
Journal: Front Oncol Date: 2017-01-31 Impact factor: 6.244

1 in total