Literature DB >> 25374761

Protein kinases are potential targets to treat inflammatory bowel disease.

Lei Yang1, Yutao Yan1.   

Abstract

Protein kinases play a crucial role in the pathogenesis of inflammatory bowel disease (IBD), the two main forms of which are ulcerative colitis and Crohn's disease. In this article, we will review the mechanisms of involvement of protein kinases in the pathogenesis of and intervention against IBD, in terms of their effects on genetics, microbiota, mucous layer and tight junction, and the potential of protein kinases as therapeutic targets against IBD.

Entities:  

Keywords:  Barrier function; Genetics; Inflammatory bowel disease; Microbiota; Protein kinase

Year:  2014        PMID： 25374761      PMCID： PMC4218950          DOI： 10.4292/wjgpt.v5.i4.209

Source DB:  PubMed          Journal:  World J Gastrointest Pharmacol Ther        ISSN： 2150-5349


  106 in total

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2.  Protein kinase C-theta mediates negative feedback on regulatory T cell function.

Authors:  Alexandra Zanin-Zhorov; Yi Ding; Sudha Kumari; Mukundan Attur; Keli L Hippen; Maryanne Brown; Bruce R Blazar; Steven B Abramson; Juan J Lafaille; Michael L Dustin
Journal:  Science       Date:  2010-03-25       Impact factor: 47.728

Review 3.  Genetics and pathogenesis of inflammatory bowel disease.

Authors:  Bernard Khor; Agnès Gardet; Ramnik J Xavier
Journal:  Nature       Date:  2011-06-15       Impact factor: 49.962

4.  MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.

Authors:  S C Corr; E M Palsson-McDermott; I Grishina; S P Barry; G Aviello; N J Bernard; P G Casey; J B J Ward; S J Keely; S Dandekar; P G Fallon; L A J O'Neill
Journal:  Mucosal Immunol       Date:  2013-04-24       Impact factor: 7.313

5.  A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells.

Authors:  Roberta Caruso; Daniele Fina; Ilaria Peluso; Carmine Stolfi; Massimo Claudio Fantini; Valentina Gioia; Flavio Caprioli; Giovanna Del Vecchio Blanco; Omero Alessandro Paoluzi; Thomas T Macdonald; Francesco Pallone; Giovanni Monteleone
Journal:  Gastroenterology       Date:  2006-10-01       Impact factor: 22.682

6.  Epidermal growth factor system regulates mucin production in airways.

Authors:  K Takeyama; K Dabbagh; H M Lee; C Agustí; J A Lausier; I F Ueki; K M Grattan; J A Nadel
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-16       Impact factor: 11.205

7.  Epithelial NEMO links innate immunity to chronic intestinal inflammation.

Authors:  Arianna Nenci; Christoph Becker; Andy Wullaert; Ralph Gareus; Geert van Loo; Silvio Danese; Marion Huth; Alexei Nikolaev; Clemens Neufert; Blair Madison; Deborah Gumucio; Markus F Neurath; Manolis Pasparakis
Journal:  Nature       Date:  2007-03-14       Impact factor: 49.962

8.  Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes.

Authors:  M Quaranta; A D Burden; C E M Griffiths; J Worthington; J N Barker; R C Trembath; F Capon
Journal:  Genes Immun       Date:  2009-07-09       Impact factor: 2.676

9.  Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA.

Authors:  Denise Kelly; Jamie I Campbell; Timothy P King; George Grant; Emmelie A Jansson; Alistair G P Coutts; Sven Pettersson; Shaun Conway
Journal:  Nat Immunol       Date:  2003-12-21       Impact factor: 25.606

10.  Protein kinase C-η controls CTLA-4-mediated regulatory T cell function.

Authors:  Kok-Fai Kong; Guo Fu; Yaoyang Zhang; Tadashi Yokosuka; Javier Casas; Ann J Canonigo-Balancio; Stephane Becart; Gisen Kim; John R Yates; Mitchell Kronenberg; Takashi Saito; Nicholas R J Gascoigne; Amnon Altman
Journal:  Nat Immunol       Date:  2014-04-06       Impact factor: 25.606
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  5 in total

1.  Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.

Authors:  Maria Laura Santoru; Cristina Piras; Antonio Murgia; Vanessa Palmas; Tania Camboni; Sonia Liggi; Ivan Ibba; Maria Antonia Lai; Sandro Orrù; Sylvain Blois; Anna Lisa Loizedda; Julian Leether Griffin; Paolo Usai; Pierluigi Caboni; Luigi Atzori; Aldo Manzin
Journal:  Sci Rep       Date:  2017-08-25       Impact factor: 4.379

Review 2.  The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.

Authors:  Sunil Thomas; Jacques Izard; Emily Walsh; Kristen Batich; Pakawat Chongsathidkiet; Gerard Clarke; David A Sela; Alexander J Muller; James M Mullin; Korin Albert; John P Gilligan; Katherine DiGuilio; Rima Dilbarova; Walker Alexander; George C Prendergast
Journal:  Cancer Res       Date:  2017-03-14       Impact factor: 12.701

3.  Computational drug repurposing for inflammatory bowel disease using genetic information.

Authors:  Liam Grenier; Pingzhao Hu
Journal:  Comput Struct Biotechnol J       Date:  2019-01-07       Impact factor: 7.271

Review 4.  Overview of Immunological Responses and Immunomodulation Properties of Trichuris sp.: Prospects for Better Understanding Human Trichuriasis.

Authors:  Dewi Masyithah Darlan; Muhammad Fakhrur Rozi; Hemma Yulfi
Journal:  Life (Basel)       Date:  2021-02-27

5.  Microbiota, not host origin drives ex vivo intestinal epithelial responses.

Authors:  Kaline Arnauts; Padhmanand Sudhakar; Sare Verstockt; Cynthia Lapierre; Selina Potche; Clara Caenepeel; Bram Verstockt; Jeroen Raes; Séverine Vermeire; João Sabino; Catherine Verfaillie; Marc Ferrante
Journal:  Gut Microbes       Date:  2022 Jan-Dec
  5 in total

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