BACKGROUND: Hypertension, homocysteine and renal resistive index are associated with atherosclerosis and lead to cardiovascular diseases. In this study, we aimed to investigate the association between homocysteine and renal resistive index in patients with newly diagnosed hypertension. METHODS: A total of 221 subjects were included in this case-control study. The study group consisted of 116 hypertensive patients and the control group consisted of 105 healthy subjects. Renal resistive index, homocysteine levels, insulin concentrations and blood pressures were measured. RESULTS: Renal resistive index, serum homocysteine levels and insulin concentrations were higher in hypertensive patients (p = 0.006, p < 0.001, respectively). Serum homocysteine levels were associated with hypertension (OR 9.5, Cl 95 % 4.86-18.7, p < 0.001). Homocysteine and insulin levels were positively correlated with renal resistive index (r = 0.372, p = 0.001; r = 0.392, p < 0.001, respectively). CONCLUSION: High renal resistive index in hypertensive patients is associated with homocysteine.
BACKGROUND:Hypertension, homocysteine and renal resistive index are associated with atherosclerosis and lead to cardiovascular diseases. In this study, we aimed to investigate the association between homocysteine and renal resistive index in patients with newly diagnosed hypertension. METHODS: A total of 221 subjects were included in this case-control study. The study group consisted of 116 hypertensivepatients and the control group consisted of 105 healthy subjects. Renal resistive index, homocysteine levels, insulin concentrations and blood pressures were measured. RESULTS: Renal resistive index, serum homocysteine levels and insulin concentrations were higher in hypertensivepatients (p = 0.006, p < 0.001, respectively). Serum homocysteine levels were associated with hypertension (OR 9.5, Cl 95 % 4.86-18.7, p < 0.001). Homocysteine and insulin levels were positively correlated with renal resistive index (r = 0.372, p = 0.001; r = 0.392, p < 0.001, respectively). CONCLUSION: High renal resistive index in hypertensivepatients is associated with homocysteine.
Authors: Belén Ponte; Menno Pruijm; Daniel Ackermann; Philippe Vuistiner; Ute Eisenberger; Idris Guessous; Valentin Rousson; Markus G Mohaupt; Heba Alwan; Georg Ehret; Antoinette Pechere-Bertschi; Fred Paccaud; Jan A Staessen; Bruno Vogt; Michel Burnier; Pierre-Yves Martin; Murielle Bochud Journal: Hypertension Date: 2013-10-14 Impact factor: 10.190