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Literature DB >> 25373772

Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis.

Abstract

Microtubules can target proteins such as Connexin43 to plasma membrane subdomains. Patel et al. (2014) now show that the structural desmosome complex participates in targeted trafficking of membrane components through interactions between the microtubule network and the N terminus of desmoplakin, a region that is a pathogenic mutation hotspot.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2014 PMID： 25373772 PMCID： PMC4620127 DOI： 10.1016/j.devcel.2014.10.010

Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270

9 in total

1. Dynein binds to beta-catenin and may tether microtubules at adherens junctions.

Authors: L A Ligon; S Karki; M Tokito; E L Holzbaur
Journal: Nat Cell Biol Date: 2001-10 Impact factor: 28.824

2. Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization.

Authors: Halina S Chkourko; Guadalupe Guerrero-Serna; Xianming Lin; Nedal Darwish; Joshua R Pohlmann; Keith E Cook; Jeffrey R Martens; Eli Rothenberg; Hassan Musa; Mario Delmar
Journal: Heart Rhythm Date: 2012-03-07 Impact factor: 6.343

3. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions.

Authors: Robin M Shaw; Alex J Fay; Manojkumar A Puthenveedu; Mark von Zastrow; Yuh-Nung Jan; Lily Y Jan
Journal: Cell Date: 2007-02-09 Impact factor: 41.582

4. Microtubule plus-end and minus-end capture at adherens junctions is involved in the assembly of apico-basal arrays in polarised epithelial cells.

Authors: Gemma Bellett; Jane M Carter; Jennifer Keynton; Deborah Goldspink; Colin James; David K Moss; Mette M Mogensen
Journal: Cell Motil Cytoskeleton Date: 2009-10

5. A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.

Authors: Angeliki Asimaki; Harikrishna Tandri; Hayden Huang; Marc K Halushka; Shiva Gautam; Cristina Basso; Gaetano Thiene; Adalena Tsatsopoulou; Nikos Protonotarios; William J McKenna; Hugh Calkins; Jeffrey E Saffitz
Journal: N Engl J Med Date: 2009-03-12 Impact factor: 91.245

6. A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.

Authors: James W Smyth; Shan-Shan Zhang; Jose M Sanchez; Samy Lamouille; Jacob M Vogan; Geoffrey G Hesketh; Tingting Hong; Gordon F Tomaselli; Robin M Shaw
Journal: Traffic Date: 2014-04-09 Impact factor: 6.215

7. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.

Authors: Angeliki Asimaki; Sudhir Kapoor; Eva Plovie; Anne Karin Arndt; Edward Adams; ZhenZhen Liu; Cynthia A James; Daniel P Judge; Hugh Calkins; Jared Churko; Joseph C Wu; Calum A MacRae; André G Kléber; Jeffrey E Saffitz
Journal: Sci Transl Med Date: 2014-06-11 Impact factor: 17.956

8. Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium.

Authors: James W Smyth; Ting-Ting Hong; Danchen Gao; Jacob M Vogan; Brian C Jensen; Tina S Fong; Paul C Simpson; Didier Y R Stainier; Neil C Chi; Robin M Shaw
Journal: J Clin Invest Date: 2009-12-28 Impact factor: 14.808

9. Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.

Authors: Dipal M Patel; Adi D Dubash; Geri Kreitzer; Kathleen J Green
Journal: J Cell Biol Date: 2014-09-15 Impact factor: 10.539

9 in total

5 in total

Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis.

1. Dynein binds to beta-catenin and may tether microtubules at adherens junctions.

2. Remodeling of mechanical junctions and of microtubule-associated proteins accompany cardiac connexin43 lateralization.

3. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions.

4. Microtubule plus-end and minus-end capture at adherens junctions is involved in the assembly of apico-basal arrays in polarised epithelial cells.

5. A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.

6. A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia.

7. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy.

8. Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium.

9. Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions.

Review 1. Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention.

Review 2. Desmosome regulation and signaling in disease.

Review 3. Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium.

Review 4. The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking.

Review 5. Intracellular trafficking pathways of Cx43 gap junction channels.