Literature DB >> 25373598

6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA.

Muhammet Tanc1, Fabrizio Carta, Andrea Scozzafava, Claudiu T Supuran.   

Abstract

A series of 6-substituted 2-benzoxathiine-2,2-dioxides were synthesized starting from 2,5-dihydroxybenzaldehyde, and then screened in vitro for their inhibition properties against five human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms. All the compounds showed excellent selectivity against the mitochondrial (hCA VA) and the tumor associated (hCA IX and XII) enzymes.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25373598     DOI： 10.1039/c4ob02155j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Stereocontrolled Synthesis of the Fully Glycosylated Monomeric Unit of Lomaiviticin A.

Authors:  Zhi Xu; Mikaela DiBello; Zechun Wang; John A Rose; Lei Chen; Xin Li; Seth B Herzon
Journal:  J Am Chem Soc       Date:  2022-08-23       Impact factor: 16.383

2.  Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII.

Authors:  Simone Giovannuzzi; Clemente Capasso; Alessio Nocentini; Claudiu T Supuran
Journal:  Molecules       Date:  2022-06-24       Impact factor: 4.927

Review 3.  Progress in the synthesis of δ-sultones.

Authors:  Christina Gaunersdorfer; Mario Waser
Journal:  Monatsh Chem       Date:  2017-07-15       Impact factor: 1.451

4.  Sequence Analysis, Kinetic Constants, and Anion Inhibition Profile of the Nacrein-Like Protein (CgiNAP2X1) from the Pacific Oyster Magallana gigas (Ex-Crassostrea gigas).

Authors:  Rosa Perfetto; Sonia Del Prete; Daniela Vullo; Giovanni Sansone; Carmela M A Barone; Mosè Rossi; Claudiu T Supuran; Clemente Capasso
Journal:  Mar Drugs       Date:  2017-08-28       Impact factor: 5.118

5.  Photosensitive nanocarriers for specific delivery of cargo into cells.

Authors:  Pedro Mena-Giraldo; Sandra Pérez-Buitrago; Maritza Londoño-Berrío; Isabel C Ortiz-Trujillo; Lina M Hoyos-Palacio; Jahir Orozco
Journal:  Sci Rep       Date:  2020-02-07       Impact factor: 4.379

6.  Olefination with Sulfonyl Halides and Esters: Synthesis of Unsaturated Sulfonyl Fluorides.

Authors:  Michał Tryniszewski; Dariusz Basiak; Michał Barbasiewicz
Journal:  Org Lett       Date:  2022-06-02       Impact factor: 6.072
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.