| Literature DB >> 25373495 |
Xiao-Hui Zheng1, Qian Cao, Yi-Liang Ding, Yi-Fang Zhong, Ge Mu, Peter Z Qin, Liang-Nian Ji, Zong-Wan Mao.
Abstract
Two porphyrin-bridged tetranuclear platinum(II) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression.Entities:
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Year: 2015 PMID： 25373495 DOI： 10.1039/c4dt02760d
Source DB: PubMed Journal: Dalton Trans ISSN： 1477-9226 Impact factor: 4.390